Neuropeptide FF/neuropeptide AF receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Catherine Mollereau-Manaute; Lionel Moulédous; Michel Roumy; Kazuyoshi Tsutsui; Takayoshi Ubuka; Jean-Marie Zajac

doi:10.2218/gtopdb/F43/2019.4

Neuropeptide FF/neuropeptide AF receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Catherine Mollereau-Manaute CNRS Toulouse
Lionel Moulédous Université Paul Sabatier
Michel Roumy CNRS Toulouse
Kazuyoshi Tsutsui Waseda University https://orcid.org/0000-0002-6261-3035
Takayoshi Ubuka Monash University Malaysia https://orcid.org/0000-0002-4731-8118
Jean-Marie Zajac CNRS Toulouse

Abstract

The Neuropeptide FF receptor family contains two subtypes, NPFF1 and NPFF2 (provisional nomenclature [10]), which exhibit high affinities for neuropeptide FF (NPFF, O15130) and RFamide related peptides (RFRP: precursor gene symbol NPVF, Q9HCQ7). NPFF1 is broadly distributed in the central nervous system with the highest levels found in the limbic system and the hypothalamus. NPFF2 is present in high density in the superficial layers of the mammalian spinal cord where it is involved in nociception and modulation of opioid functions.

DOI: https://doi.org/10.2218/gtopdb/F43/2019.4

Published

16-Sep-2019

How to Cite

Mollereau-Manaute, C., Moulédous, L., Roumy, M., Tsutsui, K., Ubuka, T. and Zajac, J.-M. (2019) “Neuropeptide FF/neuropeptide AF receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F43/2019.4.

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Issue

Vol 2019 No 4 (2019)

Section

Summaries

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