Melanocortin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Abstract
Melanocortin receptors (provisional nomenclature as recommended by NC-IUPHAR [36]) are activated by members of the melanocortin family (α-MSH, β-MSH and γ-MSH forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH). Endogenous antagonists include agouti and agouti-related protein. ACTH(1-24) was approved by the US FDA as a diagnostic agent for adrenal function test, whilst NDP-MSH was approved by EMA for the treatment of erythropoietic protoporphyria. Several synthetic melanocortin receptor agonists are under clinical development.
Published
16-Sep-2019
How to Cite
Caruso, V., Chai, B.-X., Clark, A. J. L., Cone, R. D., Eberle, A. N., Farooqi, S., Fong, T. M., Gantz, I., Haskell-Luevano, C., Hruby, V. J., Mountjoy, K. G., Pouton, C., Schiöth, H., Tatro, J. B. and Wikberg, J. E. S. (2019) “Melanocortin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F38/2019.4.
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