Glycoprotein hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  • Sabine Costagliola Université Libre de Bruxelles
  • James A. Dias New York State Department of Health
  • Marvin Gershengorn National Institutes of Health
  • Deborah L. Segaloff University of Iowa
  • Axel P.N. Themmen Erasmus University Medical Cente
  • Gilbert Vassart Université Libre de Bruxelles

Abstract


Glycoprotein hormone receptors (provisional nomenclature [45]) are activated by a non-covalent heterodimeric glycoprotein made up of a common α chain (glycoprotein hormone common alpha subunit CGA, P01215), with a unique β chain that confers the biological specificity to FSH, LH, hCG or TSH. There is binding cross-reactivity across the endogenous agonists for each of the glycoprotein hormone receptors. The deglycosylated hormones appear to exhibit reduced efficacy at these receptors [120].
DOI: https://doi.org/10.2218/gtopdb/F30/2019.4
Published
16-Sep-2019
How to Cite
Costagliola, S., Dias, J. A., Gershengorn, M., Segaloff, D. L., Themmen, A. P. and Vassart, G. (2019) “Glycoprotein hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F30/2019.4.
Issue
Vol 2019 No 4 (2019)
Section
Summaries
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