Free fatty acid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Celia Briscoe; Andrew Brown; Nick Holliday; Stephen Jenkinson; Graeme Milligan; Amy E. Monaghan; Leigh Stoddart

doi:10.2218/gtopdb/F24/2019.4

Free fatty acid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Celia Briscoe Johnson & Johnson Pharmaceutical Research & Development
Andrew Brown GlaxoSmithKline https://orcid.org/0000-0002-5616-3664
Nick Holliday University of Nottingham https://orcid.org/0000-0002-2900-828X
Stephen Jenkinson Tanabe Research Laboratories
Graeme Milligan University of Glasgow https://orcid.org/0000-0002-6946-3519
Amy E. Monaghan University of Edinburgh
Leigh Stoddart University of Glasgow https://orcid.org/0000-0002-4469-0600

Abstract

Free fatty acid receptors (FFA, nomenclature as agreed by the NC-IUPHAR Subcommittee on free fatty acid receptors [111, 24]) are activated by free fatty acids. Long-chain saturated and unsaturated fatty acids (including C14.0 (myristic acid), C16:0 (palmitic acid), C18:1 (oleic acid), C18:2 (linoleic acid), C18:3, (α-linolenic acid), C20:4 (arachidonic acid), C20:5,n-3 (EPA) and C22:6,n-3 (docosahexaenoic acid)) activate FFA1 [8, 50, 60] and FFA4 receptors [41, 48, 90], while short chain fatty acids (C2 (acetic acid), C3 (propanoic acid), C4 (butyric acid) and C5 (pentanoic acid)) activate FFA2 [9, 62, 86] and FFA3 [9, 62] receptors. The crystal structure for agonist bound FFA1 has been described [108].

DOI: https://doi.org/10.2218/gtopdb/F24/2019.4

Published

16-Sep-2019

How to Cite

Briscoe, C., Brown, A., Holliday, N., Jenkinson, S., Milligan, G., Monaghan, A. E. and Stoddart, L. (2019) “Free fatty acid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F24/2019.4.

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Issue

Vol 2019 No 4 (2019)

Section

Summaries

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