Adhesion Class GPCRs (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  • Demet Arac-Ozkan University of Chicago https://orcid.org/0000-0002-5444-5799
  • Gabriela Aust University of Leipzig https://orcid.org/0000-0002-4670-4543
  • Tom I. Bonner National Institute of Mental Health
  • Heike Cappallo-Obermann University of Hamburg
  • Caroline Formstone King's College London
  • Jörg Hamann University of Amsterdam
  • Breanne Harty Washington University
  • Henrike Heyne University of Leipzig
  • Christiane Kirchhoff University of Hamburg
  • Barbara Knapp Johannes-Gutenberg Universitaet Mainz
  • Arunkumar Krishnan Uppsala Universitet
  • Tobias Langenhan University of Leipzig https://orcid.org/0000-0002-9061-3809
  • Diana Le Duc University of Leipzig
  • Hsi-Hsien Lin Chang Gung University
  • David C. Martinelli Stanford University
  • Kelly Monk Washington University
  • Xianhua Piao Boston Children's Hospital
  • Simone Prömel University of Leipzig
  • Torsten Schöneberg University of Leipzig
  • Helgi Schiöth Uppsala University
  • Kathleen Singer Boston Children's Hospital
  • Martin Stacey University of Leeds
  • Yuri Ushkaryov University of Kent
  • Uwe Wolfrum Johannes-Gutenberg Universitaet Mainz
  • Lei Xu University of Rochester

Abstract


Adhesion GPCRs are structurally identified on the basis of a large extracellular region, similar to the Class B GPCR, but which is linked to the 7TM region by a GPCR autoproteolysis-inducing (GAIN) domain [8] containing a GPCR proteolytic site. The N-terminus often shares structural homology with adhesive domains (e.g. cadherins, immunolobulin, lectins) facilitating inter- and matricellular interactions and leading to the term adhesion GPCR [82, 332]. Several receptors have been suggested to function as mechanosensors [254, 234, 315, 32]. The nomenclature of these receptors was revised in 2015 as recommended by NC-IUPHAR and the Adhesion GPCR Consortium [100].
Published
16-Sep-2019
How to Cite
Arac-Ozkan, D., Aust, G., Bonner, T. I., Cappallo-Obermann, H., Formstone, C., Hamann, J., Harty, B., Heyne, H., Kirchhoff, C., Knapp, B., Krishnan, A., Langenhan, T., Le Duc, D., Lin, H.-H., Martinelli, D. C., Monk, K., Piao, X., Prömel, S., Schöneberg, T., Schiöth, H., Singer, K., Stacey, M., Ushkaryov, Y., Wolfrum, U. and Xu, L. (2019) “Adhesion Class GPCRs (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F17/2019.4.
Section
Summaries