Apelin receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
The apelin receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee on the apelin receptor ) responds to apelin, a 36 amino-acid peptide derived initially from bovine stomach. apelin-36, apelin-13 and [Pyr1]apelin-13 are the predominant endogenous ligands which are cleaved from a 77 amino-acid precursor peptide (APLN, Q9ULZ1) by a so far unidentified enzymatic pathway . A second family of peptides discovered independently and named Elabela  or Toddler, that has little sequence similarity to apelin, is present, and functional at the apelin receptor in the adult cardiovascular system [87, 67]. Structure-activity relationship Elabela analogues have been described .
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