5-Hydroxytryptamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Abstract
5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [194] and subsequently revised [176]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversity of metabotropic 5-HT receptors is increased by alternative splicing that produces isoforms of the 5-HT2A (non-functional), 5-HT2C (non-functional), 5-HT4, 5-HT6 (non-functional) and 5-HT7 receptors. Unique amongst the GPCRs, RNA editing produces 5-HT2C receptor isoforms that differ in function, such as efficiency and specificity of coupling to Gq/11 and also pharmacology [40, 482]. Most 5-HT receptors (except 5-ht1e and 5-ht5b) play specific roles mediating functional responses in different tissues (reviewed by [463, 382]).
Published
16-Sep-2019
How to Cite
Andrade, R., Barnes, N. M., Baxter, G., Bockaert, J., Branchek, T., Butler, A., Cohen, M. L., Dumuis, A., Eglen, R. M., Göthert, M., Hamblin, M., Hamon, M., Hartig, P. R., Hen, R., Hensler, J., Herrick-Davis, K., Hills, R., Hoyer, D., Humphrey, P. P. A., Latté, K. P., Maroteaux, L., Martin, G. R., Middlemiss, D. N., Mylecharane, E., Neumaier, J., Peroutka, S. J., Peters, J. A., Roth, B., Saxena, P. R., Sharp, T., Sleight, A., Villalon, C. M. and Yocca, F. (2019) “5-Hydroxytryptamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F1/2019.4.
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