5-Hydroxytryptamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  • Rodrigo Andrade Wayne State University https://orcid.org/0000-0002-3969-7840
  • Nicholas M. Barnes University of Birmingham
  • Gordon Baxter Pharmagene Laboratories
  • Joel Bockaert Wayne State University
  • Theresa Branchek Synaptic Pharmaceutical Corporation
  • Amy Butler University of Birmingham
  • Marlene L. Cohen Lilly Research Laboratories
  • Aline Dumuis Université de Montpellier
  • Richard M. Eglen PerkinElmer
  • Manfred Göthert Universität Bonn
  • Mark Hamblin Puget Sound Geriatric Research Education and Clinical Center
  • Michel Hamon Sorbonne Université
  • Paul R. Hartig DuPont-Merck Pharmaceutical Company
  • René Hen Columbia University
  • Julie Hensler University of Texas
  • Katharine Herrick-Davis Albany Medical College
  • Rebecca Hills University of Edinburgh
  • Daniel Hoyer University of Melbourne https://orcid.org/0000-0002-1405-7089
  • Patrick P. A. Humphrey University of Cambridge
  • Klaus Peter Latté Axxonis Pharma AG
  • Luc Maroteaux Sorbonne University https://orcid.org/0000-0002-9499-8603
  • Graeme R. Martin Discovery-Insight
  • Derek N. Middlemiss GlaxoSmithKline
  • Ewan Mylecharane University of Sydney
  • John Neumaier University of Washington
  • Stephen J. Peroutka PPD Pharmaceuticals
  • John A. Peters University of Dundee https://orcid.org/0000-0002-4277-4245
  • Bryan Roth University of North Carolina
  • Pramod R. Saxena Erasmus Universiteit Rotterdam
  • Trevor Sharp University of Oxford
  • Andrew Sleight Hoffman-La Roche
  • Carlos M. Villalon Cinvestav
  • Frank Yocca Bristol-Myers Squibb


5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [194] and subsequently revised [176]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversity of metabotropic 5-HT receptors is increased by alternative splicing that produces isoforms of the 5-HT2A (non-functional), 5-HT2C (non-functional), 5-HT4, 5-HT6 (non-functional) and 5-HT7 receptors. Unique amongst the GPCRs, RNA editing produces 5-HT2C receptor isoforms that differ in function, such as efficiency and specificity of coupling to Gq/11 and also pharmacology [40, 482]. Most 5-HT receptors (except 5-ht1e and 5-ht5b) play specific roles mediating functional responses in different tissues (reviewed by [463, 382]).
How to Cite
Andrade, R., Barnes, N. M., Baxter, G., Bockaert, J., Branchek, T., Butler, A., Cohen, M. L., Dumuis, A., Eglen, R. M., Göthert, M., Hamblin, M., Hamon, M., Hartig, P. R., Hen, R., Hensler, J., Herrick-Davis, K., Hills, R., Hoyer, D., Humphrey, P. P. A., Latté, K. P., Maroteaux, L., Martin, G. R., Middlemiss, D. N., Mylecharane, E., Neumaier, J., Peroutka, S. J., Peters, J. A., Roth, B., Saxena, P. R., Sharp, T., Sleight, A., Villalon, C. M. and Yocca, F. (2019) “5-Hydroxytryptamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database”, IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi: 10.2218/gtopdb/F1/2019.4.