IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F334/2023.1

Tumour necrosis factor (TNF) receptor family in GtoPdb v.2023.1



David MacEwan1
  1. University of Liverpool, UK


Abstract

Dysregulated TNFR signalling is associated with many inflammatory disorders, including some forms of arthritis and inflammatory bowel disease, and targeting TNF has been an effective therapeutic strategy in these diseases and for cancer immunotherapy [5, 6, 49].

Contents

This is a citation summary for Tumour necrosis factor (TNF) receptor family in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [8].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Tumour necrosis factor (TNF) receptor family
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=334
Introduction to Tumour necrosis factor (TNF) receptor family
https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=334
    Receptors
            TNFR1(tumor necrosis factor receptor 1)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1870
            TNFR2(tumor necrosis factor receptor 2)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1871
            lymphotoxin β receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1872
            OX40
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1873
            CD40
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1874
            Fas
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1875
            decoy receptor 3
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2322
            CD27
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1876
            CD30
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1877
            4-1BB
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1878
            DR4(death receptor 4)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1879
            DR5(death receptor 5)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1880
            decoy receptor 1
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2323
            decoy receptor 2
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2324
            RANK(receptor activator of NF-kappa B)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1881
            OPG(osteoprotegerin)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1882
            DR3(death receptor 3)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1883
            TWEAK receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1884
            TACI
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1885
            BAFF-R(BAFF receptor)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1886
            HVEM(herpes virus entry mediator)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1887
            nerve growth factor receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1888
            BCMA(B cell maturation antigen)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1889
            GITR(glucocorticoid-induced TNF receptor)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1890
            TAJ(toxicity and JNK inducer)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1891
            RELT
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1892
            DR6(death receptor 6)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1893
            TNFRSF22
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1894
            TNFRSF23
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1895
            ectodysplasin A2 isoform receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1896
            ectodysplasin 1, anhidrotic receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2325

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