IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F260/2023.1

Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs) in GtoPdb v.2023.1



Chen Yan1
  1. University of Rochester, USA


Abstract

3',5'-Cyclic nucleotide phosphodiesterases (PDEs, 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase), E.C. 3.1.4.17, catalyse the hydrolysis of a 3',5'-cyclic nucleotide (usually cyclic AMP or cyclic GMP). isobutylmethylxanthine is a nonselective inhibitor with an IC50 value in the millimolar range for all isoforms except PDE 8A, 8B and 9A. A 2',3'-cyclic nucleotide 3'-phosphodiesterase (E.C. 3.1.4.37 CNPase) activity is associated with myelin formation in the development of the CNS.

Contents

This is a citation summary for Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs) in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [13].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs)
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=260
Introduction to Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs)
https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=260
    Enzymes
            PDE1A(phosphodiesterase 1A)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1294
            PDE1B(phosphodiesterase 1B)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1295
            PDE1C(phosphodiesterase 1C)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1296
            PDE2A(phosphodiesterase 2A)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1297
            PDE3A(phosphodiesterase 3A)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1298
            PDE3B(phosphodiesterase 3B)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1299
            PDE4A(phosphodiesterase 4A)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1300
            PDE4B(phosphodiesterase 4B)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1301
            PDE4C(phosphodiesterase 4C)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1302
            PDE4D(phosphodiesterase 4D)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1303
            PDE5A(phosphodiesterase 5A)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1304
            PDE6A(phosphodiesterase 6A)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1312
            PDE6B(phosphodiesterase 6B)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1313
            PDE6C(phosphodiesterase 6C)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1314
            PDE6D(phosphodiesterase 6D)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1315
            PDE6G(phosphodiesterase 6G)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1316
            PDE6H(phosphodiesterase 6H)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1317
            PDE7A(phosphodiesterase 7A)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1305
            PDE7B(phosphodiesterase 7B)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1306
            PDE8A(phosphodiesterase 8A)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1307
            PDE8B(phosphodiesterase 8B)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1308
            PDE9A(phosphodiesterase 9A)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1309
            PDE10A(phosphodiesterase 10A)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1310
            PDE11A(phosphodiesterase 11A)
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1311

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