IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F147/2023.1

SLC25 family of mitochondrial transporters in GtoPdb v.2023.1



Edmund R.S. Kunji1
  1. University of Cambridge, UK


Abstract

Mitochondrial carriers are nuclear-encoded proteins, which translocate solutes across the inner mitochondrial membrane. Mitochondrial carriers are functional as monomers and have six TM alpha-helices and the termini in the mitochondrial intermembrane space.

Contents

This is a citation summary for SLC25 family of mitochondrial transporters in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [1].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

SLC25 family of mitochondrial transporters
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=147
    Mitochondrial di- and tri-carboxylic acid transporter subfamily
    https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=203
        Transporters
                CIC(Mitochondrial citrate transporter)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1051
                DIC(Mitochondrial dicarboxylate transporter)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1052
                OGC(Mitochondrial oxoglutarate carrier)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1053
                ODC(Mitochondrial oxodicarboxylate carrier)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1057
                SLC25A34
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1085
                SLC25A35
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1086
    Mitochondrial amino acid transporter subfamily
    https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=204
        Transporters
                solute carrier family 25 member 47
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2558
                solute carrier family 25 member 48
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2559
                AGC1
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1054
                AGC2
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1055
                GC2(Mitochondrial glutamate carrier 2)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1056
                GC1(Mitochondrial glutamate carrier 1)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1058
                ORC2(Mitochondrial ornithine transporter 2)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1059
                ORC1(Mitochondrial ornithine transporter 1 )
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1060
                CAC(Carnitine/acylcarnitine carrier)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1076
                ORNT3
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1081
                SLC25A38
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1089
                CGI-69
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1090
                MCFP
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1091
                SLC25A44
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1094
                SLC25A45
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1095
    Mitochondrial phosphate transporters
    https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=205
        Transporters
                PHC(Mitochondrial phosphate carrier)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1061
    Mitochondrial nucleotide transporter subfamily
    https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=206
        Transporters
                ANT1(Mitochondrial adenine nucleotide translocator 1)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1062
                ANT2(Mitochondrial adenine nucleotide translocator 2)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1063
                ANT3(Mitochondrial adenine nucleotide translocator 3)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1064
                ANT4(Mitochondrial adenine nucleotide translocator 4)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1065
                GDC(Graves disease carrier)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1071
                PMP34(Peroxisomal membrane protein)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1072
                DNC(Deoxynucleotide carrier 1)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1073
                SAMC1(S-Adenosylmethionine carrier)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1074
                SLC25A42
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1075
                APC1(Mitochondrial phosphate carrier 1)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1077
                APC2(Mitochondrial phosphate carrier 2)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1078
                APC3(Mitochondrial phosphate carrier 3)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1079
                MFTC(MFT)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1083
                PNC1
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1084
                PNC2(SLC25A36)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1087
                SCaMC-3L
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1092
                SLC25A43
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1093
    Mitochondrial uncoupling proteins
    https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=207
        Transporters
                UCP1(Uncoupling protein 1)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1066
                UCP2(Uncoupling protein 2)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1067
                UCP3(Uncoupling protein 3)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1068
                UCP4(Uncoupling protein 4)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1069
                UCP5(Uncoupling protein 5)
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1070
                KMCP1
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1082
    Miscellaneous SLC25 mitochondrial transporters
    https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=209
        Transporters
                mitochondrial carrier 1
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2554
                mitochondrial carrier 2
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2555
                solute carrier family 25 member 51
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2560
                solute carrier family 25 member 52
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2561
                solute carrier family 25 member 53
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2562
                Mitoferrin2
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1080
                Mitoferrin1
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1088
                SLC25A46
                https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1096

References

  1. Buneman P, Christie G, Davies JA, Dimitrellou R, Harding SD, Pawson AJ, Sharman JL and Wu Y. (2020) Why data citation isn't working, and what to do about it Database 2020 [PMID:32367113]
  2. Fiermonte G, Dolce V, David L, Santorelli FM, Dionisi-Vici C, Palmieri F and Walker JE. (2003) The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms. J Biol Chem 278: 32778-83 [PMID:12807890]
  3. Fiermonte G, Paradies E, Todisco S, Marobbio CM and Palmieri F. (2009) A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitochondria. J Biol Chem 284: 18152-9 [PMID:19429682]