IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F91/2023.1

2A. Hepatocyte nuclear factor-4 receptors in GtoPdb v.2023.1



Frances M. Sladek1
  1. University of California Riverside, USA


Abstract

The nomenclature of hepatocyte nuclear factor-4 receptors is agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [9, 3]. While linoleic acid has been identified as the endogenous ligand for HNF4α its function remains ambiguous [75]. HNF4γ has yet to be paired with an endogenous ligand.

Contents

This is a citation summary for 2A. Hepatocyte nuclear factor-4 receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [11].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

2A. Hepatocyte nuclear factor-4 receptors
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=91
Introduction to 2A. Hepatocyte nuclear factor-4 receptors
https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=91
    Receptors
            Hepatocyte nuclear factor-4-α
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=608
            Hepatocyte nuclear factor-4-γ
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=609

References

  1. Aguilar-Salinas CA, Reyes-Rodríguez E, Ordóñez-Sánchez ML, Torres MA, Ramírez-Jiménez S, Domínguez-López A, Martínez-Francois JR, Velasco-Pérez ML, Alpizar M, García-García E, Gómez-Pérez F, Rull J and Tusié-Luna MT. (2001) Early-onset type 2 diabetes: metabolic and genetic characterization in the mexican population. J Clin Endocrinol Metab 86: 220-6 [PMID:11232004]
  2. Akiyama TE and Gonzalez FJ. (2003) Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors. Biochim Biophys Acta 1619: 223-34 [PMID:12573481]
  3. Alexander SPH, Cidlowski JA, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD and Pawson AJ et al.. (2019) THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Nuclear hormone receptors. Br J Pharmacol 176 Suppl 1: S229-S246 [PMID:31710718]
  4. Arbini AA, Pollak ES, Bayleran JK, High KA and Bauer KA. (1997) Severe factor VII deficiency due to a mutation disrupting a hepatocyte nuclear factor 4 binding site in the factor VII promoter. Blood 89: 176-82 [PMID:8978290]
  5. Archer A, Sauvaget D, Chauffeton V, Bouchet PE, Chambaz J, Pinçon-Raymond M, Cardot P, Ribeiro A and Lacasa M. (2005) Intestinal apolipoprotein A-IV gene transcription is controlled by two hormone-responsive elements: a role for hepatic nuclear factor-4 isoforms. Mol Endocrinol 19: 2320-34 [PMID:15928313]
  6. Argyrokastritis A, Kamakari S, Kapsetaki M, Kritis A, Talianidis I and Moschonas NK. (1997) Human hepatocyte nuclear factor-4 (hHNF-4) gene maps to 20q12-q13.1 between PLCG1 and D20S17. Hum Genet 99: 233-6 [PMID:9048927]
  7. Avraham KB, Prezioso VR, Chen WS, Lai E, Sladek FM, Zhong W, Darnell JE, Jenkins NA and Copeland NG. (1992) Murine chromosomal location of four hepatocyte-enriched transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and HNF-4. Genomics 13: 264-8 [PMID:1612587]
  8. Barrio R, Bellanné-Chantelot C, Moreno JC, Morel V, Calle H, Alonso M and Mustieles C. (2002) Nine novel mutations in maturity-onset diabetes of the young (MODY) candidate genes in 22 Spanish families. J Clin Endocrinol Metab 87: 2532-9 [PMID:12050210]
  9. Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J, Sladek F, Tsai MJ and Laudet V. (2006) International Union of Pharmacology. LXVI. Orphan nuclear receptors. Pharmacol Rev 58: 798-836 [PMID:17132856]
  10. Bogan AA, Dallas-Yang Q, Ruse MD, Maeda Y, Jiang G, Nepomuceno L, Scanlan TS, Cohen FE and Sladek FM. (2000) Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha. J Mol Biol 302: 831-51 [PMID:10993727]
  11. Buneman P, Christie G, Davies JA, Dimitrellou R, Harding SD, Pawson AJ, Sharman JL and Wu Y. (2020) Why data citation isn't working, and what to do about it Database 2020 [PMID:32367113]
  12. Chartier FL, Bossu JP, Laudet V, Fruchart JC and Laine B. (1994) Cloning and sequencing of cDNAs encoding the human hepatocyte nuclear factor 4 indicate the presence of two isoforms in human liver. Gene 147: 269-72 [PMID:7926813]
  13. Chen WS, Manova K, Weinstein DC, Duncan SA, Plump AS, Prezioso VR, Bachvarova RF and Darnell JE. (1994) Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev 8: 2466-77 [PMID:7958910]
  14. Chou WC, Prokova V, Shiraishi K, Valcourt U, Moustakas A, Hadzopoulou-Cladaras M, Zannis VI and Kardassis D. (2003) Mechanism of a transcriptional cross talk between transforming growth factor-beta-regulated Smad3 and Smad4 proteins and orphan nuclear receptor hepatocyte nuclear factor-4. Mol Biol Cell 14: 1279-94 [PMID:12631740]
  15. Drewes T, Senkel S, Holewa B and Ryffel GU. (1996) Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes. Mol Cell Biol 16: 925-31 [PMID:8622695]
  16. Duncan SA, Manova K, Chen WS, Hoodless P, Weinstein DC, Bachvarova RF and Darnell JE. (1994) Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc Natl Acad Sci USA 91: 7598-602 [PMID:8052626]
  17. Duncan SA, Nagy A and Chan W. (1997) Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4(-/-) embryos. Development 124: 279-87 [PMID:9053305]
  18. Eeckhoute J, Moerman E, Bouckenooghe T, Lukoviak B, Pattou F, Formstecher P, Kerr-Conte J, Vandewalle B and Laine B. (2003) Hepatocyte nuclear factor 4 alpha isoforms originated from the P1 promoter are expressed in human pancreatic beta-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms. Endocrinology 144: 1686-94 [PMID:12697672]
  19. Furuta H, Iwasaki N, Oda N, Hinokio Y, Horikawa Y, Yamagata K, Yano N, Sugahiro J, Ogata M and Ohgawara H et al.. (1997) Organization and partial sequence of the hepatocyte nuclear factor-4 alpha/MODY1 gene and identification of a missense mutation, R127W, in a Japanese family with MODY. Diabetes 46: 1652-7 [PMID:9313765]
  20. Galson DL, Tsuchiya T, Tendler DS, Huang LE, Ren Y, Ogura T and Bunn HF. (1995) The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1. Mol Cell Biol 15: 2135-44 [PMID:7891708]
  21. Gragnoli C, Lindner T, Cockburn BN, Kaisaki PJ, Gragnoli F, Marozzi G and Bell GI. (1997) Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4 alpha binding site in the promoter of the hepatocyte nuclear factor-1 alpha gene. Diabetes 46: 1648-51 [PMID:9313764]
  22. Gupta RK and Kaestner KH. (2004) HNF-4alpha: from MODY to late-onset type 2 diabetes. Trends Mol Med 10: 521-4 [PMID:15519277]
  23. Hall RK, Sladek FM and Granner DK. (1995) The orphan receptors COUP-TF and HNF-4 serve as accessory factors required for induction of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids. Proc Natl Acad Sci USA 92: 412-6 [PMID:7831301]
  24. Hani EH, Suaud L, Boutin P, Chèvre JC, Durand E, Philippi A, Demenais F, Vionnet N, Furuta H, Velho G, Bell GI, Laine B and Froguel P. (1998) A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus. J Clin Invest 101: 521-6 [PMID:9449683]
  25. Hata S, Inoue T, Kosuga K, Nakashima T, Tsukamoto T and Osumi T. (1995) Identification of two splice isoforms of mRNA for mouse hepatocyte nuclear factor 4 (HNF-4). Biochim Biophys Acta 1260: 55-61 [PMID:7999795]
  26. Hata S, Tsukamoto T and Osumi T. (1992) A novel isoform of rat hepatocyte nuclear factor 4 (HNF-4). Biochim Biophys Acta 1131: 211-3 [PMID:1610903]
  27. Hayhurst GP, Lee YH, Lambert G, Ward JM and Gonzalez FJ. (2001) Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol 21: 1393-403 [PMID:11158324]
  28. Hu C and Perlmutter DH. (1999) Regulation of alpha1-antitrypsin gene expression in human intestinal epithelial cell line caco-2 by HNF-1alpha and HNF-4. Am J Physiol 276: G1181-94 [PMID:10330009]
  29. Jiang G, Nepomuceno L, Hopkins K and Sladek FM. (1995) Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors. Mol Cell Biol 15: 5131-43 [PMID:7651430]
  30. Jiang G and Sladek FM. (1997) The DNA binding domain of hepatocyte nuclear factor 4 mediates cooperative, specific binding to DNA and heterodimerization with the retinoid X receptor alpha. J Biol Chem 272: 1218-25 [PMID:8995424]
  31. Kardassis D, Pardali K and Zannis VI. (2000) SMAD proteins transactivate the human ApoCIII promoter by interacting physically and functionally with hepatocyte nuclear factor 4. J Biol Chem 275: 41405-14 [PMID:10995777]
  32. Kardassis D, Tzameli I, Hadzopoulou-Cladaras M, Talianidis I and Zannis V. (1997) Distal apolipoprotein C-III regulatory elements F to J act as a general modular enhancer for proximal promoters that contain hormone response elements. Synergism between hepatic nuclear factor-4 molecules bound to the proximal promoter and distal enhancer sites. Arterioscler Thromb Vasc Biol 17: 222-32 [PMID:9012660]
  33. Kiselyuk A, Lee SH, Farber-Katz S, Zhang M, Athavankar S, Cohen T, Pinkerton AB, Ye M, Bushway P and Richardson AD et al.. (2012) HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol 19: 806-18 [PMID:22840769]
  34. Ktistaki E and Talianidis I. (1997) Modulation of hepatic gene expression by hepatocyte nuclear factor 1. Science 277: 109-12 [PMID:9204893]
  35. Ktistaki E and Talianidis I. (1997) Chicken ovalbumin upstream promoter transcription factors act as auxiliary cofactors for hepatocyte nuclear factor 4 and enhance hepatic gene expression. Mol Cell Biol 17: 2790-7 [PMID:9111350]
  36. Kuo CJ, Conley PB, Chen L, Sladek FM, Darnell JE and Crabtree GR. (1992) A transcriptional hierarchy involved in mammalian cell-type specification. Nature 355: 457-61 [PMID:1734282]
  37. Lausen J, Thomas H, Lemm I, Bulman M, Borgschulze M, Lingott A, Hattersley AT and Ryffel GU. (2000) Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degree. Nucleic Acids Res 28: 430-7 [PMID:10606640]
  38. Lee YK, Dell H, Dowhan DH, Hadzopoulou-Cladaras M and Moore DD. (2000) The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression. Mol Cell Biol 20: 187-95 [PMID:10594021]
  39. Lehto M, Bitzén PO, Isomaa B, Wipemo C, Wessman Y, Forsblom C, Tuomi T, Taskinen MR and Groop L. (1999) Mutation in the HNF-4alpha gene affects insulin secretion and triglyceride metabolism. Diabetes 48: 423-5 [PMID:10334325]
  40. Lin J, Puigserver P, Donovan J, Tarr P and Spiegelman BM. (2002) Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem 277: 1645-8 [PMID:11733490]
  41. Maeda Y, Rachez C, Hawel L, Byus CV, Freedman LP and Sladek FM. (2002) Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205. Mol Endocrinol 16: 1502-10 [PMID:12089346]
  42. Malik S, Wallberg AE, Kang YK and Roeder RG. (2002) TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4. Mol Cell Biol 22: 5626-37 [PMID:12101254]
  43. Metzger S, Halaas JL, Breslow JL and Sladek FM. (1993) Orphan receptor HNF-4 and bZip protein C/EBP alpha bind to overlapping regions of the apolipoprotein B gene promoter and synergistically activate transcription. J Biol Chem 268: 16831-8 [PMID:8344962]
  44. Mietus-Snyder M, Sladek FM, Ginsburg GS, Kuo CF, Ladias JA, Darnell JE and Karathanasis SK. (1992) Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. Mol Cell Biol 12: 1708-18 [PMID:1312668]
  45. Monney CT, Kaltenrieder V, Cousin P, Bonny C and Schorderet DF. (2002) Large Family With Maturity-Onset Diabetes of the Young and a Novel V121I Mutation in HNF4A. Hum Mutat 20: 230-1 [PMID:12203996]
  46. Muller YL, Infante AM, Hanson RL, Love-Gregory L, Knowler W, Bogardus C and Baier LJ. (2005) Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians. Diabetes 54: 3035-9 [PMID:16186411]
  47. Møller AM, Dalgaard LT, Ambye L, Hansen L, Schmitz O, Hansen T and Pedersen O. (1999) A novel Phe75fsdelT mutation in the hepatocyte nuclear factor-4alpha gene in a Danish pedigree with maturity-onset diabetes of the young. J Clin Endocrinol Metab 84: 367-9 [PMID:9920109]
  48. Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI and Young RA. (2004) Control of pancreas and liver gene expression by HNF transcription factors. Science 303: 1378-81 [PMID:14988562]
  49. Oxombre B, Kouach M, Moerman E, Formstecher P and Laine B. (2004) The G115S mutation associated with maturity-onset diabetes of the young impairs hepatocyte nuclear factor 4alpha activities and introduces a PKA phosphorylation site in its DNA-binding domain. Biochem J 383: 573-80 [PMID:15233628]
  50. Oxombre B, Moerman E, Eeckhoute J, Formstecher P and Laine B. (2002) Mutations in hepatocyte nuclear factor 4alpha (HNF4alpha) gene associated with diabetes result in greater loss of HNF4alpha function in pancreatic beta-cells than in nonpancreatic beta-cells and in reduced activation of the apolipoprotein CIII promoter in hepatic cells. J Mol Med 80: 423-30 [PMID:12110948]
  51. Ozeki T, Takahashi Y, Kume T, Nakayama K, Yokoi T, Nunoya K, Hara A and Kamataki T. (2001) Co-operative regulation of the transcription of human dihydrodiol dehydrogenase (DD)4/aldo-keto reductase (AKR)1C4 gene by hepatocyte nuclear factor (HNF)-4alpha/gamma and HNF-1alpha. Biochem J 355: 537-44 [PMID:11284743]
  52. Parviz F, Li J, Kaestner KH and Duncan SA. (2002) Generation of a conditionally null allele of hnf4alpha. Genesis 32: 130-3 [PMID:11857799]
  53. Parviz F, Matullo C, Garrison WD, Savatski L, Adamson JW, Ning G, Kaestner KH, Rossi JM, Zaret KS and Duncan SA. (2003) Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. Nat Genet 34: 292-6 [PMID:12808453]
  54. Price JA, Fossey SC, Sale MM, Brewer CS, Freedman BI, Wuerth JP and Bowden DW. (2000) Analysis of the HNF4 alpha gene in Caucasian type II diabetic nephropathic patients. Diabetologia 43: 364-72 [PMID:10768098]
  55. Pruhova S, Ek J, Lebl J, Sumnik Z, Saudek F, Andel M, Pedersen O and Hansen T. (2003) Genetic epidemiology of MODY in the Czech republic: new mutations in the MODY genes HNF-4alpha, GCK and HNF-1alpha. Diabetologia 46: 291-5 [PMID:12627330]
  56. Rha GB, Wu G, Shoelson SE and Chi YI. (2009) Multiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activation. J Biol Chem 284: 35165-76 [PMID:19846556]
  57. Rowley CW, Staloch LJ, Divine JK, McCaul SP and Simon TC. (2006) Mechanisms of mutual functional interactions between HNF-4alpha and HNF-1alpha revealed by mutations that cause maturity onset diabetes of the young. Am J Physiol Gastrointest Liver Physiol 290: G466-75 [PMID:16223942]
  58. Ruse MD, Privalsky ML and Sladek FM. (2002) Competitive cofactor recruitment by orphan receptor hepatocyte nuclear factor 4alpha1: modulation by the F domain. Mol Cell Biol 22: 1626-38 [PMID:11865043]
  59. Ryffel GU. (2001) Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences. J Mol Endocrinol 27: 11-29 [PMID:11463573]
  60. Sauvaget D, Chauffeton V, Citadelle D, Chatelet FP, Cywiner-Golenzer C, Chambaz J, Pinçon-Raymond M, Cardot P, Le Beyec J and Ribeiro A. (2002) Restriction of apolipoprotein A-IV gene expression to the intestine villus depends on a hormone-responsive element and parallels differential expression of the hepatic nuclear factor 4alpha and gamma isoforms. J Biol Chem 277: 34540-8 [PMID:12105231]
  61. Shimamoto Y, Ishida J, Yamagata K, Saito T, Kato H, Matsuoka T, Hirota K, Daitoku H, Nangaku M, Yamagata K, Fujii H, Takeda J and Fukamizu A. (2004) Inhibitory effect of the small heterodimer partner on hepatocyte nuclear factor-4 mediates bile acid-induced repression of the human angiotensinogen gene. J Biol Chem 279: 7770-6 [PMID:14672953]
  62. Sladek FM, Ruse MD, Nepomuceno L, Huang SM and Stallcup MR. (1999) Modulation of transcriptional activation and coactivator interaction by a splicing variation in the F domain of nuclear receptor hepatocyte nuclear factor 4alpha1. Mol Cell Biol 19: 6509-22 [PMID:10490591]
  63. Sladek FM and Seidel SD. (2001) Hepatocyte Nuclear Factor 4a. In Nuclear Receptors and Genetic Diseases Edited by Burris TP, McCabe ERB: Academic Press: 309-361
  64. Sladek FM, Zhong WM, Lai E and Darnell JE. (1990) Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev 4: 2353-65 [PMID:2279702]
  65. Sugiyama T, Wang JC, Scott DK and Granner DK. (2000) Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene. J Biol Chem 275: 3446-54 [PMID:10652338]
  66. Tanaka T, Jiang S, Hotta H, Takano K, Iwanari H, Sumi K, Daigo K, Ohashi R, Sugai M, Ikegame C, Umezu H, Hirayama Y, Midorikawa Y, Hippo Y, Watanabe A, Uchiyama Y, Hasegawa G, Reid P, Aburatani H, Hamakubo T, Sakai J, Naito M and Kodama T. (2006) Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer. J Pathol 208: 662-72 [PMID:16400631]
  67. Taraviras S, Mantamadiotis T, Dong-Si T, Mincheva A, Lichter P, Drewes T, Ryffel GU, Monaghan AP and Schütz G. (2000) Primary structure, chromosomal mapping, expression and transcriptional activity of murine hepatocyte nuclear factor 4gamma. Biochim Biophys Acta 1490: 21-32 [PMID:10786614]
  68. Thomas H, Jaschkowitz K, Bulman M, Frayling TM, Mitchell SM, Roosen S, Lingott-Frieg A, Tack CJ, Ellard S, Ryffel GU and Hattersley AT. (2001) A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young. Hum Mol Genet 10: 2089-97 [PMID:11590126]
  69. Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG and Kim RB. (2003) The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4. Nat Med 9: 220-4 [PMID:12514743]
  70. Wang JC, Stafford JM and Granner DK. (1998) SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4. J Biol Chem 273: 30847-50 [PMID:9812974]
  71. Wisely GB, Miller AB, Davis RG, Thornquest AD, Johnson R, Spitzer T, Sefler A, Shearer B, Moore JT, Miller AB, Willson TM and Williams SP. (2002) Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids. Structure 10: 1225-34 [PMID:12220494]
  72. Yamagata K, Furuta H, Oda N, Kaisaki PJ, Menzel S, Cox NJ, Fajans SS, Signorini S, Stoffel M and Bell GI. (1996) Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1). Nature 384: 458-60 [PMID:8945471]
  73. Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB and Spiegelman BM. (2001) Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413: 131-8 [PMID:11557972]
  74. Yoshida E, Aratani S, Itou H, Miyagishi M, Takiguchi M, Osumu T, Murakami K and Fukamizu A. (1997) Functional association between CBP and HNF4 in trans-activation. Biochem Biophys Res Commun 241: 664-9 [PMID:9434765]
  75. Yuan X, Ta TC, Lin M, Evans JR, Dong Y, Bolotin E, Sherman MA, Forman BM and Sladek FM. (2009) Identification of an endogenous ligand bound to a native orphan nuclear receptor. PLoS ONE 4: e5609 [PMID:19440305]
  76. Zhang W, Tsuchiya T and Yasukochi Y. (1999) Transitional change in interaction between HIF-1 and HNF-4 in response to hypoxia. J Hum Genet 44: 293-9 [PMID:10496070]