IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F90/2023.1

1I. Vitamin D receptor-like receptors in GtoPdb v.2023.1



Sylvia Christakos1
  1. Rutgers University, USA


Abstract

Vitamin D (VDR), Pregnane X (PXR) and Constitutive Androstane (CAR) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [50, 1]) are members of the NR1I family of nuclear receptors, which form heterodimers with members of the retinoid X receptor family. PXR and CAR are activated by a range of exogenous compounds, with no established endogenous physiological agonists, although high concentrations of bile acids and bile pigments activate PXR and CAR [50].

Contents

This is a citation summary for 1I. Vitamin D receptor-like receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [10].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

1I. Vitamin D receptor-like receptors
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=90
Introduction to 1I. Vitamin D receptor-like receptors
https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=90
    Receptors
            Vitamin D receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=605
            Pregnane X receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=606
            Constitutive androstane receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=607

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