1. Tel Aviv University, Israel
2. University of California Irvine, USA
3. Columbia University, USA
4. Ulm University, Germany
5. University of California San Francisco, USA
6. CNRS Valbonne, France
7. State University of New York at Stony Brook, USA
8. Washington University, USA
9. Max Planck Institute for Experimental Medicine, Germany
10. University of Wisconsin-Madison, USA
11. New York University, USA
12. University of Utah, USA
13. University of California Davis, USA
14. Peking Union Medical College, China

Abstract

The 6TM family of K channels comprises the voltage-gated K_V subfamilies, the EAG subfamily (which includes hERG channels), the Ca²⁺-activated Slo subfamily (actually with 7TM, termed BK) and the Ca²⁺-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. K_v1.1 with K_v1.2; K_v7.2 with K_v7.3). The pharmacology largely reflects the subunit composition of the functional channel.K_v7 channelsK_v7.1-K_v7.5 (KCNQ1-5) K⁺ channels are voltage-gated K⁺ channels with major roles in neurons, muscle cells and epithelia where they underlie physiologically important K⁺ currents, such as the neuronal M-current and the cardiac IKs. Genetic deficiencies in all five KCNQ genes result in human excitability disorders, including epilepsy, autism spectrum disorders, cardiac arrhythmias and deafness. Thanks to the recent knowledge of the structure and function of human KCNQ-encoded proteins, these channels are increasingly used as drug targets for treating diseases [326, 2, 767].

Contents

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [77].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

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