IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F62/2023.1

Tachykinin receptors in GtoPdb v.2023.1



Jeffrey Barrett1, Brenden Canning2, Joseph Coulson3, Erin Dombrowsky1, Steven D. Douglas4, Tung M. Fong5, Christa Y. Heyward1, Susan E. Leeman6 and Pranela Remeshwar7
  1. Children's Hospital of Philadelphia, USA
  2. Johns Hopkins, USA
  3. University of Edinburgh, UK
  4. University of Pennsylvania, USA
  5. Vyluma Inc, USA
  6. Boston University, USA
  7. University of Medicine and Dentistry of New Jersey, USA


Abstract

Tachykinin receptors (provisional nomenclature as recommended by NC-IUPHAR [91]) are activated by the endogenous peptides substance P (SP), neurokinin A (NKA; previously known as substance K, neurokinin α, neuromedin L), neurokinin B (NKB; previously known as neurokinin β, neuromedin K), neuropeptide K and neuropeptide γ (N-terminally extended forms of neurokinin A). The neurokinins (A and B) are mammalian members of the tachykinin family, which includes peptides of mammalian and nonmammalian origin containing the consensus sequence: Phe-x-Gly-Leu-Met. Marked species differences in in vitro pharmacology exist for all three receptors, in the context of nonpeptide ligands. Antagonists such as aprepitant and fosaprepitant were approved by FDA and EMA, in combination with other antiemetic agents, for the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy.

Contents

This is a citation summary for Tachykinin receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [29].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Tachykinin receptors
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=62
Introduction to Tachykinin receptors
https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=62
    Receptors
            NK1 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=360
            NK2 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=361
            NK3 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=362

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