IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F45/2023.1

Neuropeptide W/neuropeptide B receptors in GtoPdb v.2023.1



Anthony P. Davenport1, Janet J. Maguire1 and Gurminder Singh1
  1. University of Cambridge, UK


Abstract

The neuropeptide BW receptor 1 (NPBW1, provisional nomenclature [6]) is activated by two 23-amino-acid peptides, neuropeptide W (neuropeptide W-23) and neuropeptide B (neuropeptide B-23) [22, 7]. C-terminally extended forms of the peptides (neuropeptide W-30 and neuropeptide B-29) also activate NPBW1 [2]. Unique to both forms of neuropeptide B is the N-terminal bromination of the first tryptophan residue, and it is from this post-translational modification that the nomenclature NPB is derived. These peptides were first identified from bovine hypothalamus and therefore are classed as neuropeptides. Endogenous variants of the peptides without the N-terminal bromination, des-Br-neuropeptide B-23 and des-Br-neuropeptide B-29, were not found to be major components of bovine hypothalamic tissue extracts. The NPBW2 receptor is activated by the short and C-terminal extended forms of neuropeptide W and neuropeptide B [2].

Contents

This is a citation summary for Neuropeptide W/neuropeptide B receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [3].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Neuropeptide W/neuropeptide B receptors
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=45
Introduction to Neuropeptide W/neuropeptide B receptors
https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=45
    Receptors
            NPBW1 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=303
            NPBW2 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=304

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