1. University of California San Francisco, USA
2. University of Copenhagen, Denmark
3. Harvard University, USA
4. University of Sydney, Australia

Abstract

This set contains class C 'orphan' G protein coupled receptors where the endogenous ligand(s) is not known.

Contents

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [4].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

References

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2. Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P and O'Hara P. (2001) Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. Biochim Biophys Acta 1518: 237-248 [PMID:11311935]
3. Bräuner-Osborne H and Krogsgaard-Larsen P. (2000) Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain. Genomics 65: 121-8 [PMID:10783259]
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12. Peachey NS, Ray TA, Florijn R, Rowe LB, Sjoerdsma T, Contreras-Alcantara S, Baba K, Tosini G, Pozdeyev N and Iuvone PM et al.. (2012) GPR179 is required for depolarizing bipolar cell function and is mutated in autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet 90: 331-9 [PMID:22325362]
13. Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR and Harrington JJ et al.. (2005) Identification of a novel extracellular cation-sensing G-protein-coupled receptor. J Biol Chem 280: 40201-9 [PMID:16199532]
14. Pi M, Wu Y and Quarles LD. (2011) GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo. J Bone Miner Res 26: 1680-3 [PMID:21425331]
15. Pi M, Zhang L, Lei SF, Huang MZ, Zhu W, Zhang J, Shen H, Deng HW and Quarles LD. (2010) Impaired osteoblast function in GPRC6A null mice. J Bone Miner Res 25: 1092-102 [PMID:19874200]
16. Pillarisetti K, Edavettal S, Mendonça M, Li Y, Tornetta M, Babich A, Majewski N, Husovsky M, Reeves D and Walsh E et al.. (2020) A T-cell-redirecting bispecific G-protein-coupled receptor class 5 member D x CD3 antibody to treat multiple myeloma. Blood 135: 1232-1243 [PMID:32040549]
17. Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN and Pangalos MN. (2000) Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). Genomics 67: 8-18 [PMID:10945465]
18. Speca DJ, Lin DM, Sorensen PW, Isacoff EY, Ngai J and Dittman AH. (1999) Functional identification of a goldfish odorant receptor. Neuron 23: 487-98 [PMID:10433261]
19. Wellendorph P and Bräuner-Osborne H. (2004) Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. Gene 335: 37-46 [PMID:15194188]
20. Wellendorph P, Burhenne N, Christiansen B, Walter B, Schmale H and Bräuner-Osborne H. (2007) The rat GPRC6A: cloning and characterization. Gene 396: 257-67 [PMID:17478059]
21. Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J and Bräuner-Osborne H. (2005) Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Mol Pharmacol 67: 589-97 [PMID:15576628]
22. Xu J, Tian J and Shapiro SD. (2005) Normal lung development in RAIG1-deficient mice despite unique lung epithelium-specific expression. Am J Respir Cell Mol Biol 32: 381-387 [PMID:15677768]
23. Ye X, Tao Q, Wang Y, Cheng Y and Lotan R. (2009) Mechanisms underlying the induction of the putative human tumor suppressor GPRC5A by retinoic acid. Cancer Biol Ther 8: 951-62 [PMID:19279407]
24. Zhang YW, Mess J, Aizarani N, Mishra P, Johnson C, Romero-Mulero MC, Rettkowski J, Schönberger K, Obier N and Jäcklein K et al.. (2022) Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells. Nat Cell Biol [PMID:35725769]