IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F9/2023.1

Bombesin receptors in GtoPdb v.2023.1



Jim Battey1, Richard V. Benya2, Robert T. Jensen1 and Terry W. Moody1
  1. National Institutes of Health, USA
  2. University of Illinois at Chicago, USA


Abstract

Mammalian bombesin (Bn) receptors comprise 3 subtypes: BB1, BB2, BB3 (nomenclature recommended by the NC-IUPHAR Subcommittee on bombesin receptors, [117, 4]). BB1 and BB2 are activated by the endogenous ligands neuromedin B (NMB), gastrin-releasing peptide (GRP), and GRP-(18-27). bombesin is a tetra-decapeptide, originally derived from amphibians and structurally closely related to GRP. The three Bn receptor subtypes couple primarily to the Gq/11 and G12/13 family of G proteins [117]. Each of these receptors is widely distributed in the CNS and peripheral tissues [80, 117, 261, 290, 248, 375, 114, 164, 165]. Activation of BB1 and BB2 receptors causes a wide range of physiological/pathophysiogical actions, including the stimulation of normal and neoplastic tissue growth, smooth-muscle contraction, respiration, gastrointestinal motility, feeding behavior, secretion and many central nervous system effects including regulation of circadian rhythm, body temperature control, sighing, behavioral disorders and mediation of pruritus [153, 211, 255, 117, 205, 261, 318, 70, 35, 345, 212, 36]. BB3 is an orphan receptor, although some propose it is constitutively active [330]. BB3 receptor knockout studies show it has important roles in glucose and insulin regulation, metabolic homeostasis, feeding, regulation of body temperature, obesity, diabetes mellitus and growth of normal/neoplastic tissues [152, 80, 168, 224, 359, 209]. Bn receptors are one of the most frequently overexpressed receptors in cancers and are receiving increased attention for their roles in tumor growth, as well as for tumour imaging and for receptor-targeted cytotoxicity [211, 288, 9, 167, 171, 172, 135, 202]. Bn receptors are also receiving attention because they are one of the primary neurotransmitters for pruritus [36, 127, 35, 318].

Contents

This is a citation summary for Bombesin receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [25].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Bombesin receptors
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=9
Introduction to Bombesin receptors
https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=9
    Receptors
            BB1 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=38
            BB2 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=39
            BB3 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=40

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