1. Emory University, USA
2. Cedars-Sinai Medical Center, USA
3. National Institutes of Health, USA
4. Novartis Institutes for Biomedical Research, Switzerland
5. Cleveland Clinic Lerner Research Institute, USA
6. Temple University, USA
7. Universite de Sherbrooke, Canada
8. Veterans Administration Hospital Wisconsin, USA
9. Ehime University, Japan
10. Semmelweis University, Hungary
11. University of Alabama at Birmingham, USA
12. Vanderbilt University, USA
13. University of Queensland, Australia
14. Tularik, USA
15. Christian-Albrechts-Universität zu Kiel, Germany
16. Vrije Universiteit Brussel, Belgium

Abstract

The actions of angiotensin II (Ang II) are mediated by AT₁ and AT₂ receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Angiotensin receptors [63, 155]), which have around 30% sequence similarity. The decapeptide angiotensin I, the octapeptide angiotensin II and the heptapeptide angiotensin III are endogenous ligands. losartan, candesartan, olmesartan, telmisartan, etc. are clinically used AT₁ receptor blockers.

Contents

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [37].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

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