IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F3/2023.1

Adenosine receptors in GtoPdb v.2023.1



Bertil B. Fredholm1, Bruno G. Frenguelli2, Rebecca Hills3, Adriaan P. IJzerman4, Kenneth A. Jacobson5, Karl-Norbert Klotz6, Joel Linden7, Christa E. Müller8, Ulrich Schwabe9 and Gary L. Stiles10
  1. Karolinska Institutet, Sweden
  2. University of Warwick, UK
  3. University of Edinburgh, UK
  4. Leiden University, The Netherlands
  5. National Institutes of Health, USA
  6. Universität Würzburg, Germany
  7. La Jolla Institute for Allergy and Immunology, USA
  8. Universität Bonn, Germany
  9. Pharmakologisches Institut der Universität Heidelberg, Germany
  10. Duke University, USA


Abstract

Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Adenosine Receptors [112]) are activated by the endogenous ligand adenosine (potentially inosine also at A3 receptors). Crystal structures for the antagonist-bound [155, 316, 224, 62], agonist-bound [379, 205, 206] and G protein-bound A2A adenosine receptors [49] have been described. The structures of an antagonist-bound A1 receptor [130] and an adenosine-bound A1 receptor-Gi complex [87] have been resolved by cryo-electronmicroscopy. Another structure of an antagonist-bound A1 receptor obtained with X-ray crystallography has also been reported [58]. The structure of the A2B receptor has also been elucidated [57]. caffeine is a nonselective antagonist for adenosine receptors, while istradefylline, a selective A2A receptor antagonist, is on the market for the treatment of Parkinson's disease.

Contents

This is a citation summary for Adenosine receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [45].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Adenosine receptors
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=3
Introduction to Adenosine receptors
https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=3
    Receptors
            A1 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=18
            A2A receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=19
            A2B receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=20
            A3 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=21

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