IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F1/2023.1

5-Hydroxytryptamine receptors in GtoPdb v.2023.1

Rodrigo Andrade¹, Nicholas M. Barnes², Gordon Baxter³, Joel Bockaert¹, Theresa Branchek⁴, Amy Butler², Marlene L. Cohen⁵, Aline Dumuis⁶, Richard M. Eglen⁷, Manfred Göthert⁸, Mark Hamblin⁹, Michel Hamon¹⁰, Paul R. Hartig¹¹, René Hen¹², Julie Hensler¹³, Katharine Herrick-Davis¹⁴, Rebecca Hills¹⁵, Daniel Hoyer¹⁶, Patrick P. A. Humphrey¹⁷, Klaus Peter Latté¹⁸, Luc Maroteaux¹⁹, Graeme R. Martin²⁰, Derek N. Middlemiss²¹, Ewan Mylecharane²², John Neumaier²³, Stephen J. Peroutka²⁴, John A. Peters²⁵, Bryan Roth²⁶, Pramod R. Saxena²⁷, Trevor Sharp²⁸, Andrew Sleight²⁹, Carlos M. Villalon³⁰ and Frank Yocca³¹

Wayne State University, USA
University of Birmingham, UK
Pharmagene Laboratories, UK
Synaptic Pharmaceutical Corporation, USA
Lilly Research Laboratories, USA
Université de Montpellier, France
PerkinElmer, UK
Universität Bonn, Germany
Puget Sound Geriatric Research Education and Clinical Center, USA
Sorbonne Université, France
DuPont-Merck Pharmaceutical Company, USA
Columbia University, USA
University of Texas, USA
Albany Medical College, USA
University of Edinburgh, UK
University of Melbourne, Australia
University of Cambridge, UK
Axxonis Pharma AG, Germany
Sorbonne University, France
Discovery-Insight, USA
GlaxoSmithKline, UK
University of Sydney, Australia
University of Washington, USA
PPD Pharmaceuticals, USA
University of Dundee, UK
University of North Carolina, USA
Erasmus Universiteit Rotterdam, The Netherlands
University of Oxford, UK
Hoffman-La Roche, Switzerland
Cinvestav, Mexico
Bristol-Myers Squibb, USA

Abstract

5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [198] and subsequently revised [180]) are, with the exception of the ionotropic 5-HT₃ class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversity of metabotropic 5-HT receptors is increased by alternative splicing that produces isoforms of the 5-HT_2A (non-functional), 5-HT_2C (non-functional), 5-HT₄, 5-HT₆ (non-functional) and 5-HT₇ receptors. Unique amongst the GPCRs, RNA editing produces 5-HT_2C receptor isoforms that differ in function, such as efficiency and specificity of coupling to G_q/11 and also pharmacology [40, 491]. Most 5-HT receptors (except 5-ht_1e and 5-ht_5b) play specific roles mediating functional responses in different tissues (reviewed by [471, 387]).

This is a citation summary for 5-Hydroxytryptamine receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [80].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

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5-Hydroxytryptamine receptors in GtoPdb v.2023.1

Abstract

Contents

Database links

References