IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F1022/2021.3
Receptor guanylyl cyclase (RGC) family in GtoPdb v.2021.3
Annie Beuve1,
Peter Brouckaert2,
John C. Burnett, Jr.3,
Andreas Friebe4,
John Garthwaite5,
Adrian J. Hobbs6,
Doris Koesling7,
Michaela Kuhn8,
Lincoln R. Potter9,
Michael Russwurm10,
Harald H.H.W. Schmidt11,
Johannes-Peter Stasch12 and
Scott A. Waldman13
- Rutgers University, USA
- Vlaams Instituut voor Biotechnologie, Belgium
- Mayo Clinic, USA
- Universität Würzburg, Germany
- University College London, UK
- Queen Mary University of London, UK
- Ruhr-Universität Bochum, Germany
- Physiologisches Institut der Universität Würzburg, Germany
- University of Minnesota, USA
- Ruhr University Bochum, Germany
- Maastricht University, The Netherlands
- Bayer AG, Germany
- Thomas Jefferson University, USA
Abstract
The mammalian genome encodes seven guanylyl cyclases, GC-A to GC-G, that are homodimeric transmembrane receptors activated by a diverse range of endogenous ligands. These enzymes convert guanosine-5'-triphosphate to the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP). GC-A, GC-B and GC-C are expressed predominantly in the cardiovascular system, skeletal system and intestinal epithelium, respectively. GC-D and GC-G are found in the olfactory neuropepithelium and Grueneberg ganglion of rodents, respectively. GC-E and GC-F are expressed in retinal photoreceptors.
Contents
This is a citation summary for Receptor guanylyl cyclase (RGC) family in the
Guide to Pharmacology
database (GtoPdb). It exists purely as an adjunct to the database to
facilitate the recognition of citations to and from the database by
citation analyzers. Readers will almost certainly want to visit the
relevant sections of the database which are given here under database
links.
GtoPdb is an expert-driven
guide to pharmacological targets and the substances that act on them.
GtoPdb is a reference work which is most usefully represented as an
on-line database. As in any publication this work should be
appropriately cited, and the papers it cites should also be
recognized. This document provides a citation for the relevant parts
of the database, and also provides a reference list for the research
cited by those parts. For further details see [2].
Please note that the database version for the citations given in
GtoPdb are to the most recent preceding version
in which the family or its subfamilies and targets were substantially
changed. The links below are to the current version. If you
need to consult the cited version, rather than the most recent version, please contact
the GtoPdb curators.
Database links
Receptor guanylyl cyclase (RGC) family
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1022
Transmembrane guanylyl cyclases
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=662
Receptors
GC-A(Guanylyl cyclase-A)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1747
GC-B(Guanylyl cyclase-B)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1748
GC-C(Guanylyl cyclase-C)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1750
NPR-C(natriuretic peptide receptor 3)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1749
GC-D(Guanylyl cyclase-D)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2898
GC-E(Guanylyl cyclase-E)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2031
GC-F(Guanylyl cyclase-F)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2899
GC-G(Guanylyl cyclase-G)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2900
Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=939
Receptors
Complexes
GC-1(Guanylyl cyclase, α1β1)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1287
GC-2(Guanylyl cyclase, α2β1)
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2897
Receptors and Subunits
Guanylyl cyclase α1 subunit
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1288
Guanylyl cyclase α2 subunit
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1289
Guanylyl cyclase β1 subunit
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1290
Guanylyl cyclase β2 subunit
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1291
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