IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F27/2021.3

Galanin receptors in GtoPdb v.2021.3



Andrew L. Gundlach1 and Philip J. Ryan1
  1. University of Melbourne, Australia


Abstract

Galanin receptors (provisional nomenclature as recommended by NC-IUPHAR [57]) are activated by the endogenous peptides galanin and galanin-like peptide. Human galanin is a 30 amino-acid non-amidated peptide [52]; in other species, it is 29 amino acids long and C-terminally amidated. Amino acids 1-14 of galanin are highly conserved in mammals, birds, reptiles, amphibia and fish. Shorter peptide species (e.g. human galanin-1-19 [21] and porcine galanin-5-29 [170]) and N-terminally extended forms (e.g. N-terminally seven and nine residue elongated forms of porcine galanin [22, 170]) have been reported. More recently, the newly-identified peptide, spexin (SPX), has been reported to activate human GAL2 and GAL3 (but not GAL1) receptors in heterologous expression systems; and to alter GAL2/3 receptor-related behaviours in animals [89].

Contents

This is a citation summary for Galanin receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [31].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Galanin receptors
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=27
Introduction to Galanin receptors
https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=27
    Receptors
            GAL1 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=243
            GAL2 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=244
            GAL3 receptor
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=245

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