IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F1062/2021.2

CYP2 family: physiological enzymes subset in GtoPdb v.2021.2



Kathryn Burns1 and Nuala Ann Helsby1
  1. University of Auckland, New Zealand


Abstract

Compared to the other CYP2 family enzymes, this subset have physiological rather than drug metabolising enzyme activities.

Contents

This is a citation summary for CYP2 family: physiological enzymes subset in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [1].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

CYP2 family: physiological enzymes subset
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1062
    Enzymes
            CYP2R1
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1333
            CYP2S1
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1334
            CYP2U1
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1335
            CYP2W1
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1336

References

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  2. Cheng JB, Motola DL, Mangelsdorf DJ and Russell DW. (2003) De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase. J Biol Chem 278: 38084-93 [PMID:12867411]
  3. Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G and Korczak B. (2004) CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids. J Biol Chem 279: 6305-14 [PMID:14660610]
  4. Chung FF, Mai CW, Ng PY and Leong CO. (2016) Cytochrome P450 2W1 (CYP2W1) in Colorectal Cancers. Curr Cancer Drug Targets 16: 71-8 [PMID:26563883]
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  7. Pan Y and Ong EC. (2017) Cytochrome P450 2W1 (CYP2W1) - ready for use as the biomarker and drug target for cancer? Xenobiotica 47: 923-932 [PMID:27690753]
  8. Siller M, Goyal S, Yoshimoto FK, Xiao Y, Wei S and Guengerich FP. (2014) Oxidation of endogenous N-arachidonoylserotonin by human cytochrome P450 2U1. J Biol Chem 289: 10476-87 [PMID:24563460]
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  10. Yan P, Eng OC and Yu CJ. (2018) A Review on the Expression and Metabolic Features of Orphan Human Cytochrome P450 2S1 (CYP2S1). Curr Drug Metab 19: 917-929 [PMID:29804525]