IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F1062/2021.2
CYP2 family: physiological enzymes subset in GtoPdb v.2021.2
Kathryn Burns1 and
Nuala Ann Helsby1
- University of Auckland, New Zealand
Abstract
Compared to the other CYP2 family enzymes, this subset have physiological rather than drug metabolising enzyme activities.
Contents
This is a citation summary for CYP2 family: physiological enzymes subset in the
Guide to Pharmacology
database (GtoPdb). It exists purely as an adjunct to the database to
facilitate the recognition of citations to and from the database by
citation analyzers. Readers will almost certainly want to visit the
relevant sections of the database which are given here under database
links.
GtoPdb is an expert-driven
guide to pharmacological targets and the substances that act on them.
GtoPdb is a reference work which is most usefully represented as an
on-line database. As in any publication this work should be
appropriately cited, and the papers it cites should also be
recognized. This document provides a citation for the relevant parts
of the database, and also provides a reference list for the research
cited by those parts. For further details see [1].
Please note that the database version for the citations given in
GtoPdb are to the most recent preceding version
in which the family or its subfamilies and targets were substantially
changed. The links below are to the current version. If you
need to consult the cited version, rather than the most recent version, please contact
the GtoPdb curators.
Database links
CYP2 family: physiological enzymes subset
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1062
Enzymes
CYP2R1
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1333
CYP2S1
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1334
CYP2U1
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1335
CYP2W1
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1336
References
- Buneman P, Christie G, Davies JA, Dimitrellou R, Harding SD, Pawson AJ, Sharman JL and Wu Y. (2020) Why data citation isn't working, and what to do about it Database 2020 [PMID:32367113]
- Cheng JB, Motola DL, Mangelsdorf DJ and Russell DW. (2003) De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase. J Biol Chem 278: 38084-93 [PMID:12867411]
- Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G and Korczak B. (2004) CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids. J Biol Chem 279: 6305-14 [PMID:14660610]
- Chung FF, Mai CW, Ng PY and Leong CO. (2016) Cytochrome P450 2W1 (CYP2W1) in Colorectal Cancers. Curr Cancer Drug Targets 16: 71-8 [PMID:26563883]
- Dhers L, Ducassou L, Boucher JL and Mansuy D. (2017) Cytochrome P450 2U1, a very peculiar member of the human P450s family. Cell Mol Life Sci 74: 1859-1869 [PMID:28083596]
- Fekry MI, Xiao Y, Berg JZ and Guengerich FP. (2019) A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty Acid ω-1 Hydroxylation Using an Untargeted Metabolomic Approach. Drug Metab Dispos 47: 1325-1332 [PMID:31511258]
- Pan Y and Ong EC. (2017) Cytochrome P450 2W1 (CYP2W1) - ready for use as the biomarker and drug target for cancer? Xenobiotica 47: 923-932 [PMID:27690753]
- Siller M, Goyal S, Yoshimoto FK, Xiao Y, Wei S and Guengerich FP. (2014) Oxidation of endogenous N-arachidonoylserotonin by human cytochrome P450 2U1. J Biol Chem 289: 10476-87 [PMID:24563460]
- Xu S, Ren Z, Wang Y, Ding X and Jiang Y. (2014) Preferential expression of cytochrome CYP CYP2R1 but not CYP1B1 in human cord blood hematopoietic stem and progenitor cells. Acta Pharm Sin B 4: 464-9 [PMID:26579418]
- Yan P, Eng OC and Yu CJ. (2018) A Review on the Expression and Metabolic Features of Orphan Human Cytochrome P450 2S1 (CYP2S1). Curr Drug Metab 19: 917-929 [PMID:29804525]