IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F914/2021.2

Notch receptors in GtoPdb v.2021.2



Thiruma V. Arumugam1 and Christopher Sobey2
  1. National University of Singapore, Singapore
  2. Monash University, Australia


Abstract

Aberrant Notch signalling is implicated in a number of human cancers [18, 26, 13, 21], and there is intense pharmaceutical activity being directed towards achieving clinically effective Notch pathway inhibition [7, 16].

Contents

This is a citation summary for Notch receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [6].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Notch receptors
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=914
Introduction to Notch receptors
https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=914
    Targets
            notch receptor 1
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2861
            notch receptor 2
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2859
            notch receptor 3
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2860
            notch receptor 4
            https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2862

References

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  2. Al-Hussaini H, Subramanyam D, Reedijk M and Sridhar SS. (2011) Notch signaling pathway as a therapeutic target in breast cancer. Mol Cancer Ther 10: 9-15 [PMID:20971825]
  3. Astudillo L, Da Silva TG, Wang Z, Han X, Jin K, VanWye J, Zhu X, Weaver K, Oashi T and Lopes PE et al.. (2016) The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res 76: 3593-603 [PMID:27197169]
  4. Belver L and Ferrando A. (2016) The genetics and mechanisms of T cell acute lymphoblastic leukaemia. Nat Rev Cancer 16: 494-507 [PMID:27451956]
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  17. Nagamatsu I, Onishi H, Matsushita S, Kubo M, Kai M, Imaizumi A, Nakano K, Hattori M, Oda Y and Tanaka M et al.. (2014) NOTCH4 is a potential therapeutic target for triple-negative breast cancer. Anticancer Res 34: 69-80 [PMID:24403446]
  18. Ntziachristos P, Lim JS, Sage J and Aifantis I. (2014) From fly wings to targeted cancer therapies: a centennial for notch signaling. Cancer Cell 25: 318-34 [PMID:24651013]
  19. Puente XS, Pinyol M, Quesada V, Conde L, Ordóñez GR, Villamor N, Escaramis G, Jares P, Beà S and González-Díaz M et al.. (2011) Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 475: 101-5 [PMID:21642962]
  20. Rossi D, Rasi S, Fabbri G, Spina V, Fangazio M, Forconi F, Marasca R, Laurenti L, Bruscaggin A and Cerri M et al.. (2012) Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia. Blood 119: 521-9 [PMID:22077063]
  21. Sjölund J, Johansson M, Manna S, Norin C, Pietras A, Beckman S, Nilsson E, Ljungberg B and Axelson H. (2008) Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo. J Clin Invest 118: 217-28 [PMID:18079963]
  22. Sorrentino C, Cuneo A and Roti G. (2019) Therapeutic Targeting of Notch Signaling Pathway in Hematological Malignancies. Mediterr J Hematol Infect Dis 11: e2019037 [PMID:31308913]
  23. Stittrich AB, Lehman A, Bodian DL, Ashworth J, Zong Z, Li H, Lam P, Khromykh A, Iyer RK and Vockley JG et al.. (2014) Mutations in NOTCH1 cause Adams-Oliver syndrome. Am J Hum Genet 95: 275-84 [PMID:25132448]
  24. Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, Kryukov GV, Lawrence MS, Sougnez C and McKenna A et al.. (2011) The mutational landscape of head and neck squamous cell carcinoma. Science 333: 1157-60 [PMID:21798893]
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