IUPHAR/BPS Guide to Pharmacology CITE
SLC66 Lysosomal amino acid transporters (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database
- Universität Bern, Switzerland
This is a family of 5 evolutionarily related proteins. Their structural similarities suggest that they are transporters. Biochemical evidence supports transporter activity for SLC66A1 (LAAT1) and SLC66A4 (CTNS; Cystinosin). The functions of the 3 remaining members of the family are undetermined.
This is a citation summary for SLC66 Lysosomal amino acid transporters in the
Guide to Pharmacology
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cited by those parts.
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SLC66 Lysosomal amino acid transporters
solute carrier family 66 member 1
solute carrier family 66 member 2
solute carrier family 66 member 3
cystinosin, lysosomal cystine transporter
mannose-P-dolichol utilization defect 1
- Kalatzis V, Cherqui S, Antignac C and Gasnier B. (2001) Cystinosin, the protein defective in cystinosis, is a H(+)-driven lysosomal cystine transporter. EMBO J 20: 5940-9 [PMID:11689434]
- Liu B, Du H, Rutkowski R, Gartner A and Wang X. (2012) LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis. Science 337: 351-4 [PMID:22822152]
- Ruivo R, Bellenchi GC, Chen X, Zifarelli G, Sagné C, Debacker C, Pusch M, Supplisson S and Gasnier B. (2012) Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin. Proc Natl Acad Sci U S A 109: E210-7 [PMID:22232659]