IUPHAR/BPS Guide to Pharmacology CITE

Complement peptide receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

Antonia Cianciulli1, Liam Coulthard2, Owen Hawksworth2, John D. Lee2, Xiang X. Li3, Vincenzo Mitolo1, Peter Monk4, Maria A. Panaro1 and Trent M. Woodruff2
  1. University of Bari, Italy
  2. University of Queensland, Australia
  3. The University of Queensland, Australia
  4. Sheffield University Medical School, UK


Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [103]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement cascade. C3a and C5a exert their functions through binding to their receptors (C3aR and C5aR), causing cell activation and triggering cellular degranulation that contributes to the local inflammation.


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Database links

Complement peptide receptors
Introduction to Complement peptide receptors
            C3a receptor
            C5a1 receptor
            C5a2 receptor


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