IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F891/2020.4

Regulators of G protein Signaling (RGS) proteins (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database

Katelin E. Ahlers-Dannen¹, Mohammed Alqinyah², Christopher Bodle¹, Josephine Bou Dagher², Bandana Chakravarti¹, Shreoshi P. Choudhuri³, Kirk M. Druey⁴, Rory A. Fisher¹, Kyle J. Gerber⁵, John R. Hepler⁵, Shelley B. Hooks², Havish S. Kantheti³, Behirda Karaj⁶, Jae-Kyung Lee², Zili Luo¹, Kirill Martemyanov⁷, Luke D. Mascarenhas³, Hoa Phan Thi Nhu⁶, David L. Roman¹, Vincent Shaw⁶, Benita Sjögren⁸, Mackenzie M. Spicer¹, Katherine E. Squires⁵, Laurie Sutton⁷, Thomas M. Wilkie³, Keqiang Xie⁷ and Yalda Zolghadri³

University of Iowa, USA
University of Georgia, USA
University of Texas Southwestern Medical Center, USA
National Institutes of Health, USA
Emory University, USA
Michigan State University, USA
Scripps Research Institute, USA
Purdue University, USA

Abstract

Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subunits of heterotrimeric G proteins. RGS proteins stabilize the transition state for GTP hydrolysis on Gα and thus induce a conformational change in the Gα subunit that accelerates GTP hydrolysis, thereby effectively turning off signaling cascades mediated by GPCRs. This GTPase accelerating protein (GAP) activity is the canonical mechanism of action for RGS proteins, although many also possess additional functions and domains. RGS proteins are divided into four families, R4, R7, R12 and RZ based on sequence homology, domain structure as well as specificity towards Gα subunits. For reviews on RGS proteins and their potential as therapeutic targets, see e.g. [160, 377, 411, 415, 416, 512, 519, 312, 6].

This is a citation summary for Regulators of G protein Signaling (RGS) proteins in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

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Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

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Regulators of G protein Signaling (RGS) proteins (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database

Abstract

Contents

Database links

References