IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F58/2020.4

Prostanoid receptors (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database



Richard M. Breyer1, Lucie Clapp2, Robert A. Coleman3, Mark Giembycz4, Akos Heinemann5, Rebecca Hills6, Robert L. Jones7, Shuh Narumiya8, Xavier Norel9, Roy Pettipher10, Yukihiko Sugimoto11, Mohib Uddin12, David F. Woodward13 and Chengcan Yao6
  1. Vanderbilt University, USA
  2. University College London, UK
  3. Pharmagene Laboratories, UK
  4. University of Calgary, Canada
  5. Otto Loewi Research Center (for Vascular Biology, Immunology and Inflammation), Austria
  6. University of Edinburgh, UK
  7. University of Strathclyde, UK
  8. Kyoto University Faculty of Medicine, Japan
  9. Laboratory for Vascular Translational Science, France
  10. Atopix Therapeutics Ltd, UK
  11. Kumamoto University, Japan
  12. AstraZeneca, Sweden
  13. Allergan plc, USA


Abstract

Prostanoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Prostanoid Receptors [661]) are activated by the endogenous ligands prostaglandins PGD2, PGE1, PGE2 , PGF2α, PGH2, prostacyclin [PGI2] and thromboxane A2. Differences and similarities between human and rodent prostanoid receptor orthologues, and their specific roles in pathophysiologic conditions are reviewed in [423]. Measurement of the potency of PGI2 and thromboxane A2 is hampered by their instability in physiological salt solution; they are often replaced by cicaprost and U46619, respectively, in receptor characterization studies.

Contents

This is a citation summary for Prostanoid receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts.

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Prostanoid receptors
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=58
Introduction to Prostanoid receptors
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=58
    Receptors
            DP1 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=338
            DP2 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=339
            EP1 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=340
            EP2 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=341
            EP3 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=342
            EP4 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=343
            FP receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=344
            IP receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=345
            TP receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=346

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