IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F30/2020.4

Glycoprotein hormone receptors (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database



Sabine Costagliola1, James A. Dias2, Marvin Gershengorn3, Adam J. Pawson4, Deborah L. Segaloff5, Axel P.N. Themmen6 and Gilbert Vassart1
  1. Université Libre de Bruxelles, Belgium
  2. New York State Department of Health, USA
  3. National Institutes of Health, USA
  4. The University of Edinburgh, UK
  5. University of Iowa, USA
  6. Erasmus University Medical Cente, The Netherlands


Abstract

Glycoprotein hormone receptors (provisional nomenclature [45]) are activated by a non-covalent heterodimeric glycoprotein made up of a common α chain (glycoprotein hormone common alpha subunit CGA, P01215), with a unique β chain that confers the biological specificity to FSH, LH, hCG or TSH. There is binding cross-reactivity across the endogenous agonists for each of the glycoprotein hormone receptors. The deglycosylated hormones appear to exhibit reduced efficacy at these receptors [120].

Contents

This is a citation summary for Glycoprotein hormone receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

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Database links

Glycoprotein hormone receptors
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=30
Introduction to Glycoprotein hormone receptors
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=30
    Receptors
            FSH receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=253
            LH receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=254
            TSH receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=255

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