IUPHAR/BPS Guide to Pharmacology CITE

Hydrolases (version 2019.5) in the IUPHAR/BPS Guide to Pharmacology Database

Stephen P.H. Alexander1, Patrick Doherty2, David Fairlie3, Christopher J. Fowler4, Christopher M. Overall5, Neil Rawlings6, Christopher Southan7 and Anthony J. Turner8
  1. University of Nottingham, UK
  2. King's College London, UK
  3. University of Queensland, Australia
  4. University Hospital of Umeå, Sweden
  5. University of British Columbia, Canada
  6. Wellcome Trust Sanger Institute, UK
  7. University of Edinburgh, Sweden
  8. University of Leeds, UK


Listed in this section are hydrolases not accumulated in other parts of the Concise Guide, such as monoacylglycerol lipase and acetylcholinesterase. Pancreatic lipase is the predominant mechanism of fat digestion in the alimentary system; its inhibition is associated with decreased fat absorption. CES1 is present at lower levels in the gut than CES2 (P23141), but predominates in the liver, where it is responsible for the hydrolysis of many aliphatic, aromatic and steroid esters. Hormone-sensitive lipase is also a relatively non-selective esterase associated with steroid ester hydrolysis and triglyceride metabolism, particularly in adipose tissue. Endothelial lipase is secreted from endothelial cells and regulates circulating cholesterol in high density lipoproteins.


This is a citation summary for Hydrolases in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts.

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

            AChE(acetylcholinesterase (Cartwright blood group))
            DAGLα(Diacylglycerol lipase α)
            DAGLβ(Diacylglycerol lipase β)
            CES1(carboxylesterase 1)
            NTPDase-1(ectonucleoside triphosphate diphosphohydrolase 1)
            NTPDase-2(ectonucleoside triphosphate diphosphohydrolase 2)
            epoxide hydrolase 2
            FAAH(Fatty acid amide hydrolase)
            Leukotriene A4 hydrolase
            LIPE(lipase E, hormone sensitive type)
            LIPG(lipase G, endothelial type)
            MAGL(Monoacylglycerol lipase)
            nudix hydrolase 7
            PNLIP(pancreatic lipase)
            vanin 1


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