IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F16/2019.5

Class A Orphans (version 2019.5) in the IUPHAR/BPS Guide to Pharmacology Database



Stephen P.H. Alexander1, Jim Battey2, Helen E. Benson3, Richard V. Benya4, Tom I. Bonner5, Anthony P. Davenport6, Satoru Eguchi7, Anthony Harmar3, Nick Holliday1, Robert T. Jensen2, Sadashiva Karnik8, Evi Kostenis9, Wen Chiy Liew3, Amy E. Monaghan3, Chido Mpamhanga10, Richard Neubig11, Adam J. Pawson3, Jean-Philippe Pin12, Joanna L. Sharman3, Michael Spedding13, Eliot Spindel14, Leigh Stoddart15, Laura Storjohann16, Walter G. Thomas17, Kalyan Tirupula8 and Patrick Vanderheyden18
  1. University of Nottingham, UK
  2. National Institutes of Health, USA
  3. University of Edinburgh, UK
  4. University of Illinois at Chicago, USA
  5. National Institute of Mental Health, USA
  6. University of Cambridge, UK
  7. Temple University, USA
  8. Cleveland Clinic Lerner Research Institute, USA
  9. University of Bonn, Germany
  10. LifeArc, UK
  11. Michigan State University, USA
  12. Université de Montpellier, France
  13. Spedding Research Solutions SARL, France
  14. Oregon Health & Science University, USA
  15. University of Glasgow, UK
  16. University of Utah, USA
  17. University of Queensland, Australia
  18. Vrije Universiteit Brussel, Belgium


Abstract

Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [194], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have recently been reviewed in detail [150]. The GPCRs in Table 1 are all Class A, rhodopsin-like GPCRs. Class A orphan GPCRs not listed in Table 1 are putative GPCRs with as-yet unidentified endogenous ligands.

Table 1: Class A orphan GPCRs with putative endogenous ligands

GPR3GPR4GPR6GPR12GPR15GPR17GPR20
GPR22GPR26GPR31GPR34GPR35GPR37GPR39
GPR50GPR63GRP65GPR68GPR75GPR84GPR87
GPR88GPR132GPR149GPR161GPR183LGR4LGR5
LGR6MAS1MRGPRDMRGPRX1MRGPRX2P2RY10TAAR2

In addition the orphan receptors GPR18, GPR55 and GPR119 which are reported to respond to endogenous agents analogous to the endogenous cannabinoid ligands have been grouped together (GPR18, GPR55 and GPR119).

Contents

This is a citation summary for Class A Orphans in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts.

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Class A Orphans
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=16
Introduction to Class A Orphans
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=16
    Receptors
            BB3 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=40
            GPR3
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=83
            GPR4
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=84
            GPR6
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=85
            GPR42
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=228
            GPR12
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=86
            GPR15
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=87
            GPR17
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=88
            GPR18
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=89
            GPR19
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=90
            GPR20
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=91
            GPR21
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=92
            GPR22
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=93
            GPR25
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=95
            GPR26
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=96
            GPR27
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=97
            GPR31
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=98
            GPR32
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=99
            GPR33
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=100
            GPR34
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=101
            GPR35
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=102
            GPR37
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=103
            GPR37L1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=104
            GPR39
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=105
            GPR45
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=106
            GPR50
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=107
            GPR52
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=108
            GPR55
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=109
            GPR61
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=110
            GPR62
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=111
            GPR63
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=112
            GPR65
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=113
            GPR68
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=114
            GPR75
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=115
            GPR78
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=116
            GPR79
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=117
            GPR82
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=118
            GPR83
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=119
            GPR84
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=120
            GPR85
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=121
            GPR87
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=122
            GPR88
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=123
            GPR101
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=125
            GPR119
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=126
            GPR132
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=128
            GPR135
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=129
            GPR139
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=130
            GPR141
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=131
            GPR142
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=132
            GPR146
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=133
            GPR148
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=134
            GPR149
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=135
            GPR150
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=136
            GPR151
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=137
            GPR152
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=138
            GPR153
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=139
            GPR160
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=140
            GPR161
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=141
            GPR162
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=142
            GPR171
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=143
            GPR173
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=144
            GPR174
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=145
            GPR176
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=637
            GPR182
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=146
            GPR183
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=81
            LGR4
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=147
            LGR5
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=148
            LGR6
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=149
            MAS1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=150
            MAS1L
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=151
            MRGPRD
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=152
            MRGPRE
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=153
            MRGPRF
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=154
            MRGPRG
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=155
            MRGPRX1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=156
            MRGPRX2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=157
            MRGPRX3
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=158
            MRGPRX4
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=159
            P2RY8
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=164
            P2RY10
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=165
            TAAR2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=167
            TAAR3
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=168
            TAAR4P
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=169
            TAAR5
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=170
            TAAR6
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=171
            TAAR8
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=172
            TAAR9
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=173

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