IUPHAR/BPS Guide to Pharmacology CITE

Regulators of G protein Signaling (RGS) proteins (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Mohammed Alqinyah1, Christopher Bodle2, Josephine Bou Dagher1, Bandana Chakravarti2, Shreoshi P. Choudhuri3, Kirk M. Druey4, Rory A. Fisher2, Kyle J. Gerber5, John R. Hepler5, Shelley B. Hooks1, Havish S. Kantheti3, Behirda Karaj6, Jae-Kyung Lee1, Zili Luo2, Kirill Martemyanov7, Luke D. Mascarenhas3, Hoa Phan Thi Nhu6, David L. Roman2, Vincent Shaw6, Benita Sjögren8, Katherine E. Squires5, Laurie Sutton7, Thomas M. Wilkie3, Keqiang Xie7 and Yalda Zolghadri3
  1. University of Georgia, USA
  2. University of Iowa, USA
  3. University of Texas Southwestern Medical Center, USA
  4. National Institutes of Health, USA
  5. Emory University, USA
  6. Michigan State University, USA
  7. Scripps Research Institute, USA
  8. Purdue University, USA


Regulators of G protein signalling (RGS) proteins display a common RGS domain that interacts with the GTP-bound Gα subunits of heterotrimeric G proteins, enhancing GTP hydrolysis by stabilising the transition state [29, 419, 418], leading to a termination of GPCR signalling. Interactions through protein:protein interactions of many RGS proteins have been identified for targets other than heteromeric G proteins. Sequence analysis of the 20 RGS proteins suggests four families of RGS: RZ, R4, R7 and R12 families. Many of these proteins have been identified to have effects other than through targetting G proteins. Included here is RGS4 for which a number of pharmacological inhibitors have been described.


This is a citation summary for Regulators of G protein Signaling (RGS) proteins in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts.

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Regulators of G protein Signaling (RGS) proteins
    RZ family
                RGS17(regulator of G-protein signaling 17)
                RGS19(regulator of G-protein signaling 19)
                RGS20(regulator of G-protein signaling 20)
    R4 family
                RGS1(regulator of G-protein signaling 1)
                RGS2(regulator of G-protein signaling 2)
                RGS3(regulator of G-protein signaling 3)
                RGS4(regulator of G-protein signaling 4)
                RGS5(regulator of G-protein signaling 5)
                RGS8(regulator of G-protein signaling 8)
                RGS13(regulator of G-protein signaling 13)
                RGS16(regulator of G-protein signaling 16)
                RGS18(regulator of G-protein signaling 18)
                RGS21(regulator of G-protein signaling 21)
    R7 family
                RGS6(regulator of G-protein signaling 6)
                RGS7(regulator of G-protein signaling 7)
                RGS9(regulator of G-protein signaling 9)
                RGS11(regulator of G-protein signaling 11)
    R12 family
                RGS10(regulator of G-protein signaling 10)
                RGS12(regulator of G-protein signaling 12)
                RGS14(regulator of G-protein signaling 14)


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