IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F338/2019.4

Chemerin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



Anthony P. Davenport1 and Amy E. Monaghan2
  1. University of Cambridge, UK
  2. University of Edinburgh, UK


Abstract

Nomenclature for the chemerin receptors is presented as recommended by NC-IUPHAR [14, 41]). The chemoattractant protein and adipokine, chemerin, has been shown to be the endogenous ligand for both chemerin family receptors. Chemerin1 was the founding family member, and when GPR1 was de-orphanised it was re-named Chermerin2 [41]. Chemerin1 is also activated by the lipid-derived, anti-inflammatory ligand resolvin E1 (RvE1), which is formed via the sequential metabolism of EPA by aspirin-modified cyclooxygenase and lipoxygenase [2, 3]. In addition, two GPCRs for resolvin D1 (RvD1) have been identified: FPR2/ALX, the lipoxin A4 receptor, and GPR32, an orphan receptor [43].

Contents

This is a citation summary for Chemerin receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

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Database links

Chemerin receptors
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=338
    Receptors
            Chemerin1(chemerin receptor 1)
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=79
            Chemerin2(chemerin receptor 2)
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=82

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