IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F269/2019.4

Cyclooxygenase (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



Angelo A. Izzo1 and Jane A. Mitchell2
  1. University of Naples Federico II, Italy
  2. Imperial College London, UK


Abstract

Prostaglandin (PG) G/H synthase, most commonly referred to as cyclooxygenase (COX, (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor : oxygen oxidoreductase) activity, catalyses the formation of PGG2 from arachidonic acid. Hydroperoxidase activity inherent in the enzyme catalyses the formation of PGH2 from PGG2. COX-1 and -2 can be nonselectively inhibited by ibuprofen, ketoprofen, naproxen, indomethacin and paracetamol (acetaminophen). PGH2 may then be metabolised to prostaglandins and thromboxanes by various prostaglandin synthases in an apparently tissue-dependent manner.

Contents

This is a citation summary for Cyclooxygenase in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

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Database links

Cyclooxygenase
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=269
    Enzymes
            COX-1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1375
            COX-2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1376

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