IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F141/2019.4
SLC3 and SLC7 families of heteromeric amino acid transporters (HATs) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Yoshikatsu Kanai1
- Osaka University, Japan
Abstract
The SLC3 and SLC7 families combine to generate functional transporters, where the subunit composition is a disulphide-linked combination of a heavy chain (SLC3 family) with a light chain (SLC7 family).
Contents
This is a citation summary for SLC3 and SLC7 families of heteromeric amino acid transporters (HATs) in the
Guide to Pharmacology
database (GtoPdb). It exists purely as an adjunct to the database to
facilitate the recognition of citations to and from the database by
citation analyzers. Readers will almost certainly want to visit the
relevant sections of the database which are given here under database
links.
GtoPdb is an expert-driven
guide to pharmacological targets and the substances that act on them.
GtoPdb is a reference work which is most usefully represented as an
on-line database. As in any publication this work should be
appropriately cited, and the papers it cites should also be
recognized. This document provides a citation for the relevant parts
of the database, and also provides a reference list for the research
cited by those parts.
Please note that the database version for the citations given in
GtoPdb are to the most recent preceding version
in which the family or its subfamilies and targets were substantially
changed. The links below are to the current version. If you
need to consult the cited version, rather than the most recent version, please contact
the GtoPdb curators.
Database links
SLC3 and SLC7 families of heteromeric amino acid transporters (HATs)
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=141
SLC3 family
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=168
Transporters
rBAT
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=889
4F2hc
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=890
SLC7 family
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=169
Transporters
CAT1(High affinity cationic amino acid transporter 1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=891
CAT2(Low affinity cationic amino acid transporter 2)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=892
CAT3(Cationic amino acid transporter 3)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=893
CAT4(Cationic amino acid transporter 4)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=894
Probable cationic amino acid transporter
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=895
LAT1(L-type amino acid transporter 1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=896
LAT2(L-type amino acid transporter 2)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=897
y+LAT1(y+L amino acid transporter 1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=898
y+LAT2(y+L amino acid transporter 2)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=899
b0,+AT(b0,+-type amino acid transporter 1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=900
Asc-1(Asc-type amino acid transporter 1)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=901
xCT(Cystine/glutamate transporter)
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=902
AGT1
http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=903
References
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- Hayashi K and Anzai N. (2017) Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment. World J Gastrointest Oncol 9: 21-29 [PMID:28144396]
- Hayashi K, Jutabha P, Endou H, Sagara H and Anzai N. (2013) LAT1 is a critical transporter of essential amino acids for immune reactions in activated human T cells. J. Immunol. 191: 4080-5 [PMID:24038088]
- Hayashi K, Jutabha P, Kamai T, Endou H and Anzai N. (2014) LAT1 is a central transporter of essential amino acids in human umbilical vein endothelial cells. J. Pharmacol. Sci. 124: 511-3 [PMID:24671056]
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- Nii T, Segawa H, Taketani Y, Tani Y, Ohkido M, Kishida S, Ito M, Endou H, Kanai Y and Takeda E et al.. (2001) Molecular events involved in up-regulating human Na+-independent neutral amino acid transporter LAT1 during T-cell activation. Biochem. J. 358: 693-704 [PMID:11535130]
- Oda K, Hosoda N, Endo H, Saito K, Tsujihara K, Yamamura M, Sakata T, Anzai N, Wempe MF and Kanai Y et al.. (2010) L-type amino acid transporter 1 inhibitors inhibit tumor cell growth. Cancer Sci. 101: 173-9 [PMID:19900191]
- Papin-Michault C, Bonnetaud C, Dufour M, Almairac F, Coutts M, Patouraux S, Virolle T, Darcourt J and Burel-Vandenbos F. (2016) Study of LAT1 Expression in Brain Metastases: Towards a Better Understanding of the Results of Positron Emission Tomography Using Amino Acid Tracers. PLoS ONE 11: e0157139 [PMID:27276226]
- Park K. (2017) Insight into brain-targeted drug delivery via LAT1-utilizing prodrugs. J Control Release 261: 368 [PMID:28780138]
- Puris E, Gynther M, Huttunen J, Petsalo A and Huttunen KM. (2017) L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs. J Control Release 261: 93-104 [PMID:28662899]
- Ren W, Liu G, Yin J, Tan B, Wu G, Bazer FW, Peng Y and Yin Y. (2017) Amino-acid transporters in T-cell activation and differentiation. Cell Death Dis 8: e2655 [PMID:28252650]
- Wolf S, Janzen A, Vékony N, Martiné U, Strand D and Closs EI. (2002) Expression of solute carrier 7A4 (SLC7A4) in the plasma membrane is not sufficient to mediate amino acid transport activity. Biochem. J. 364: 767-75 [PMID:12049641]
- Yamauchi K, Sakurai H, Kimura T, Wiriyasermkul P, Nagamori S, Kanai Y and Kohno N. (2009) System L amino acid transporter inhibitor enhances anti-tumor activity of cisplatin in a head and neck squamous cell carcinoma cell line. Cancer Lett. 276: 95-101 [PMID:19058911]