IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F104/2019.4

Lanosterol biosynthesis pathway (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



Helen E. Benson1
  1. University of Edinburgh, UK


Abstract

Lanosterol is a precursor for cholesterol, which is synthesized primarily in the liver in a pathway often described as the mevalonate or HMG-CoA reductase pathway. The first two steps (formation of acetoacetyl CoA and the mitochondrial generation of (S)-3-hydroxy-3-methylglutaryl-CoA) are also associated with oxidation of fatty acids.

Contents

This is a citation summary for Lanosterol biosynthesis pathway in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

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Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Lanosterol biosynthesis pathway
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=104
Introduction to Lanosterol biosynthesis pathway
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=104
    Enzymes
            acetyl-CoA acetyltransferase 1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2435
            acetyl-CoA acetyltransferase 2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2436
            hydroxymethylglutaryl-CoA synthase 1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=638
            hydroxymethylglutaryl-CoA synthase 2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2432
            hydroxymethylglutaryl-CoA reductase
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=639
            mevalonate kinase
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=640
            phosphomevalonate kinase
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=641
            diphosphomevalonate decarboxylase
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=642
            isopentenyl-diphosphate Δ-isomerase 1
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=646
            isopentenyl-diphosphate Δ-isomerase 2
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=647
            geranylgeranyl diphosphate synthase
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=643
            farnesyl diphosphate synthase
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=644
            squalene synthase
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=645
            squalene monooxygenase
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2433
            lanosterol synthase
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2434

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