IUPHAR/BPS Guide to Pharmacology CITE

1I. Vitamin D receptor-like receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Sylvia Christakos1
  1. Rutgers University, USA


Vitamin D (VDR), Pregnane X (PXR) and Constitutive Androstane (CAR) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [47]) are members of the NR1I family of nuclear receptors, which form heterodimers with members of the retinoid X receptor family. PXR and CAR are activated by a range of exogenous compounds, with no established endogenous physiological agonists, although high concentrations of bile acids and bile pigments activate PXR and CAR [47].


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Database links

1I. Vitamin D receptor-like receptors
Introduction to 1I. Vitamin D receptor-like receptors
            Vitamin D receptor
            Pregnane X receptor
            Constitutive androstane receptor


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