IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F89/2019.4

1H. Liver X receptor-like receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



Donald P. McDonnell1 and Rachid Safi1
  1. Duke University, USA


Abstract

Liver X and farnesoid X receptors (LXR and FXR, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [68]) are members of a steroid analogue-activated nuclear receptor subfamily, which form heterodimers with members of the retinoid X receptor family. Endogenous ligands for LXRs include hydroxycholesterols (OHC), while FXRs appear to be activated by bile acids. In humans and primates, NR1H5P is a pseudogene. However, in other mammals, it encodes a functional nuclear hormone receptor that appears to be involved in cholesterol biosynthesis [71].

Contents

This is a citation summary for 1H. Liver X receptor-like receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

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Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

1H. Liver X receptor-like receptors
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=89
Introduction to 1H. Liver X receptor-like receptors
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=89
    Receptors
            Farnesoid X receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=603
            Farnesoid X receptor-β
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=604
            Liver X receptor-α
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=602
            Liver X receptor-β
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=601

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