IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F84/2019.4

1A. Thyroid hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



Douglas Forrest1, Anthony N. Hollenberg2 and Paul Webb3
  1. National Institutes of Health, USA
  2. Harvard Medical School, USA
  3. The Houston Methodist Hospital Research Institute, USA


Abstract

Thyroid hormone receptors (TRs, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [10]) are nuclear hormone receptors of the NR1A family, with diverse roles regulating macronutrient metabolism, cognition and cardiovascular homeostasis. TRs are activated by thyroxine (T4) and thyroid hormone (triiodothyronine). Once activated by a ligand, the receptor acts as a transcription factor either as a monomer, homodimer or heterodimer with members of the retinoid X receptor family. NH-3 has been described as an antagonist at TRs with modest selectivity for TRβ [38].

Contents

This is a citation summary for 1A. Thyroid hormone receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

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Database links

1A. Thyroid hormone receptors
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=84
Introduction to 1A. Thyroid hormone receptors
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=84
    Receptors
            Thyroid hormone receptor-α
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=588
            Thyroid hormone receptor-β
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=589

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