IUPHAR/BPS Guide to Pharmacology CITE

Voltage-gated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Bernard Attali1, K. George Chandy2, M. Hunter Giese3, Stephan Grissmer4, George A. Gutman2, Lily Y. Jan5, Michel Lazdunski6, David Mckinnon7, Jeanne Nerbonne8, Luis A. Pardo9, Gail A. Robertson10, Bernardo Rudy11, Michael C. Sanguinetti12, Walter Stühmer9, James S. Trimmer13 and Xiaoliang Wang14
  1. Tel Aviv University, Israel
  2. University of California Irvine, USA
  3. Columbia University, USA
  4. Ulm University, Germany
  5. University of California San Francisco, USA
  6. CNRS Valbonne, France
  7. State University of New York at Stony Brook, USA
  8. Washington University, USA
  9. Max Planck Institute for Experimental Medicine, Germany
  10. University of Wisconsin-Madison, USA
  11. New York University, USA
  12. University of Utah, USA
  13. University of California Davis, USA
  14. Peking Union Medical College, China


The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. Kv1.1 with Kv1.2; Kv7.2 with Kv7.3). The pharmacology largely reflects the subunit composition of the functional channel.


This is a citation summary for Voltage-gated potassium channels in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts.

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Voltage-gated potassium channels
Introduction to Voltage-gated potassium channels
    Channels and Subunits


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