IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F81/2019.4

Voltage-gated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Bernard Attali¹, K. George Chandy², M. Hunter Giese³, Stephan Grissmer⁴, George A. Gutman², Lily Y. Jan⁵, Michel Lazdunski⁶, David Mckinnon⁷, Jeanne Nerbonne⁸, Luis A. Pardo⁹, Gail A. Robertson¹⁰, Bernardo Rudy¹¹, Michael C. Sanguinetti¹², Walter Stühmer⁹, James S. Trimmer¹³ and Xiaoliang Wang¹⁴

Tel Aviv University, Israel
University of California Irvine, USA
Columbia University, USA
Ulm University, Germany
University of California San Francisco, USA
CNRS Valbonne, France
State University of New York at Stony Brook, USA
Washington University, USA
Max Planck Institute for Experimental Medicine, Germany
University of Wisconsin-Madison, USA
New York University, USA
University of Utah, USA
University of California Davis, USA
Peking Union Medical College, China

Abstract

The 6TM family of K channels comprises the voltage-gated K_Vsubfamilies, the EAG subfamily (which includes hERG channels), the Ca²⁺-activated Slo subfamily (actually with 7TM, termed BK) and the Ca²⁺-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. K_v1.1 with K_v1.2; K_v7.2 with K_v7.3). The pharmacology largely reflects the subunit composition of the functional channel.

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Database links

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Voltage-gated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

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