IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F67/2019.4

VIP and PACAP receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



Jan Fahrenkrug1, Edward J. Goetzl2, Illana Gozes3, Anthony Harmar4, Marc Laburthe5, Victor May6, Joseph R. Pisegna7, Sami I. Said8, David Vaudry9, Hubert Vaudry9 and James A. Waschek7
  1. University of Copenhagen, Denmark
  2. University of California San Francisco, USA
  3. Tel Aviv University, Israel
  4. University of Edinburgh, UK
  5. INSERM, France
  6. University of Vermont College of Medicine, USA
  7. University of California Los Angeles, USA
  8. State University of New York at Stony Brook, USA
  9. Normandy University, France


Abstract

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Vasoactive Intestinal Peptide Receptors [64, 65]) are activated by the endogenous peptides VIP, PACAP-38, PACAP-27, peptide histidine isoleucineamide (PHI), peptide histidine methionineamide (PHM) and peptide histidine valine (PHV). VPAC1 and VPAC2 receptors display comparable affinity for the PACAP peptides, PACAP-27 and PACAP-38, and VIP, whereas PACAP-27 and PACAP-38 are >100 fold more potent than VIP as agonists of most isoforms of the PAC1 receptor. However, one splice variant of the human PAC1 receptor has been reported to respond to PACAP-38, PACAP-27 and VIP with comparable affinity [29]. PG 99-465 [115] has been used as a selective VPAC2 receptor antagonist in a number of physiological studies, but has been reported to have significant activity at VPAC1 and PAC1 receptors [35]. The selective PAC1 receptor agonist maxadilan, was extracted from the salivary glands of sand flies (Lutzomyia longipalpis) and has no sequence homology to VIP or the PACAP peptides [116]. Two deletion variants of maxadilan, M65 [180] and Max.d.4 [117] have been reported to be PAC1 receptor antagonists, but these peptides have not been extensively characterised.

Contents

This is a citation summary for VIP and PACAP receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

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Database links

VIP and PACAP receptors
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=67
Introduction to VIP and PACAP receptors
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=67
    Receptors
            PAC1 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=370
            VPAC1 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=371
            VPAC2 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=372

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