IUPHAR/BPS Guide to Pharmacology CITE

Urotensin receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Anthony P. Davenport1, Stephen A. Douglas2, Alain Fournier3, Adel Giaid4, Henry Krum5, David G. Lambert6, Jérôme Leprince7, Margaret R. MacLean8, Eliot H. Ohlstein9, Walter G. Thomas10, Hervé Tostivint11, David Vaudry7, Hubert Vaudry7 and David J. Webb12
  1. University of Cambridge, UK
  2. Wyeth Pharmaceuticals, USA
  3. Université du Québec, Canada
  4. McGill University, Canada
  5. Monash University, Australia
  6. University of Leicester, UK
  7. Normandy University, France
  8. University of Glasgow, UK
  9. Drexel University, USA
  10. University of Queensland, Australia
  11. Muséum National d'Histoire Naturelle, France
  12. University of Edinburgh, UK


The urotensin-II (U-II) receptor (UT, nomenclature as agreed by the NC-IUPHAR Subcommittee on the Urotensin receptor [26, 36, 89]) is activated by the endogenous dodecapeptide urotensin-II, originally isolated from the urophysis, the endocrine organ of the caudal neurosecretory system of teleost fish [7, 88]. Several structural forms of U-II exist in fish and amphibians. The goby orthologue was used to identify U-II as the cognate ligand for the predicted receptor encoded by the rat gene gpr14 [20, 62, 68, 70]. Human urotensin-II, an 11-amino-acid peptide [20], retains the cyclohexapeptide sequence of goby U-II that is thought to be important in ligand binding [53, 11]. This sequence is also conserved in the deduced amino-acid sequence of rat urotensin-II (14 amino-acids) and mouse urotensin-II (14 amino-acids), although the N-terminal is more divergent from the human sequence [19]. A second endogenous ligand for the UT has been discovered in rat [83]. This is the urotensin II-related peptide, an octapeptide that is derived from a different gene, but shares the C-terminal sequence (CFWKYCV) common to U-II from other species. Identical sequences to rat urotensin II-related peptide are predicted for the mature mouse and human peptides [32]. UT exhibits relatively high sequence identity with somatostatin, opioid and galanin receptors [89].


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Urotensin receptor
Introduction to Urotensin receptor
            UT receptor


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