IUPHAR/BPS Guide to Pharmacology CITE

Trace amine receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Tom I. Bonner1, Anthony P. Davenport2, Stephen M. Foord3, Janet J. Maguire2 and William A.E. Parker2
  1. National Institute of Mental Health, USA
  2. University of Cambridge, UK
  3. GlaxoSmithKline, UK


Trace amine-associated receptors were discovered from a search for novel 5-HT receptors [9], where 15 mammalian orthologues were identified and divided into two families. The TA1 receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee for the Trace amine receptor [53]) has affinity for the endogenous trace amines tyramine, β-phenylethylamine and octopamine in addition to the classical amine dopamine [9]. Emerging evidence suggests that TA1 is a modulator of monoaminergic activity in the brain [90] with TA1 and dopamine D2 receptors shown to form constitutive heterodimers when co-expressed [28]. In addition to trace amines, receptors can be activated by amphetamine-like psychostimulants, and endogenous thyronamines.


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Database links

Trace amine receptor
Introduction to Trace amine receptor
            TA1 receptor


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