IUPHAR/BPS Guide to Pharmacology CITE

Thyrotropin-releasing hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Anthony P. Davenport1, Marvin Gershengorn2 and Rebecca Hills3
  1. University of Cambridge, UK
  2. National Institutes of Health, USA
  3. University of Edinburgh, UK


Thyrotropin-releasing hormone (TRH) receptors (provisional nomenclature as recommended by NC-IUPHAR [13]) are activated by the endogenous tripeptide TRH (pGlu-His-ProNH2). TRH and TRH analogues fail to distinguish TRH1 and TRH2 receptors [28]. [3H]TRH (human, mouse, rat) is able to label both TRH1 and TRH2 receptors with Kd values of 13 and 9 nM respectively. Synthesis and biology of ring-modified L-Histidine containing TRH analogues has been reported [22].


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Database links

Thyrotropin-releasing hormone receptors
Introduction to Thyrotropin-releasing hormone receptors
            TRH1 receptor
            TRH2 receptor


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