IUPHAR/BPS Guide to Pharmacology CITE

Tachykinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Jeffrey Barrett1, Brenden Canning2, Joseph Coulson3, Erin Dombrowsky1, Steven D. Douglas4, Tung M. Fong5, Christa Y. Heyward1, Susan E. Leeman6 and Pranela Remeshwar7
  1. Children's Hospital of Philadelphia, USA
  2. Johns Hopkins, USA
  3. University of Edinburgh, UK
  4. University of Pennsylvania, USA
  5. Covance Inc, USA
  6. Boston University, USA
  7. University of Medicine and Dentistry of New Jersey, USA


Tachykinin receptors (provisional nomenclature as recommended by NC-IUPHAR [90]) are activated by the endogenous peptides substance P (SP), neurokinin A (NKA; previously known as substance K, neurokinin α, neuromedin L), neurokinin B (NKB; previously known as neurokinin β, neuromedin K), neuropeptide K and neuropeptide γ (N-terminally extended forms of neurokinin A). The neurokinins (A and B) are mammalian members of the tachykinin family, which includes peptides of mammalian and nonmammalian origin containing the consensus sequence: Phe-x-Gly-Leu-Met. Marked species differences in in vitro pharmacology exist for all three receptors, in the context of nonpeptide ligands. Antagonists such as aprepitant and fosaprepitant were approved by FDA and EMA, in combination with other antiemetic agents, for the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy.


This is a citation summary for Tachykinin receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

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Database links

Tachykinin receptors
Introduction to Tachykinin receptors
            NK1 receptor
            NK2 receptor
            NK3 receptor


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