IUPHAR/BPS Guide to Pharmacology CITE

QRFP receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Didier Bagnol1, Tom I. Bonner2, Myrna Carlebur3, Anthony P. Davenport3, Stephen M. Foord4, Shoji Fukusumi5, Riccarda Granata6, Dan Larhammar7, Jérôme Leprince8, Janet J. Maguire3, Stefany D. Primeaux9 and Hubert Vaudry8
  1. Arena Pharmaceuticals, USA
  2. National Institute of Mental Health, USA
  3. University of Cambridge, UK
  4. GlaxoSmithKline, UK
  5. University of Tsukuba, Japan
  6. University of Torino Medical School, Italy
  7. Uppsala University, Sweden
  8. Normandy University, France
  9. Louisiana State University, USA


The human gene encoding the QRFP receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee on the QRFP receptor [16]; QRFPR, formerly known as the Peptide P518 receptor), previously designated as an orphan GPCR receptor was identified in 2001 by Lee et al. from a hypothalamus cDNA library [15]. However, the reported cDNA (AF411117) is a chimera with bases 1-127 derived from chromosome 1 and bases 155-1368 derived from chromosome 4. When corrected, QRFPR (also referred to as SP9155 or AQ27) encodes a 431 amino acid protein that shares sequence similarities in the transmembrane spanning regions with other peptide receptors. These include neuropeptide FF2 (38%), neuropeptide Y2 (37%) and galanin Gal1 (35%) receptors.


This is a citation summary for QRFP receptor in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts.

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

QRFP receptor
Introduction to QRFP receptor
            QRFP receptor


  1. Baribault H, Danao J, Gupte J, Yang L, Sun B, Richards W and Tian H. (2006) The G-protein-coupled receptor GPR103 regulates bone formation. Mol. Cell. Biol. 26: 709-17 [PMID:16382160]
  2. Bruzzone F, Lectez B, Alexandre D, Jégou S, Mounien L, Tollemer H, Chatenet D, Leprince J, Vallarino M and Vaudry H et al.. (2007) Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat. J. Comp. Neurol. 503: 573-91 [PMID:17534937]
  3. Chartrel N, Bruzzone F, Dujardin C, Leprince J, Tollemer H, Anouar Y, Vallarino M, Costentin J and Vaudry H. (2005) Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals. Ann. N. Y. Acad. Sci. 1040: 80-3 [PMID:15891009]
  4. Chartrel N, Dujardin C, Anouar Y, Leprince J, Decker A, Clerens S, Do-Régo JC, Vandesande F, Llorens-Cortes C and Costentin J et al.. (2003) Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. Proc. Natl. Acad. Sci. U.S.A. 100: 15247-52 [PMID:14657341]
  5. Davies J, Chen J, Pink R, Carter D, Saunders N, Sotiriadis G, Bai B, Pan Y, Howlett D and Payne A et al.. (2015) Orexin receptors exert a neuroprotective effect in Alzheimer's disease (AD) via heterodimerization with GPR103. Sci Rep 5: 12584 [PMID:26223541]
  6. do Rego JC, Leprince J, Chartrel N, Vaudry H and Costentin J. (2006) Behavioral effects of 26RFamide and related peptides. Peptides 27: 2715-21 [PMID:16730856]
  7. Egido EM, Hernández R, Leprince J, Chartrel N, Vaudry H, Marco J and Silvestre RA. (2007) 26RFa, a novel orexigenic neuropeptide, inhibits insulin secretion in the rat pancreas. Peptides 28: 725-30 [PMID:16777265]
  8. Fukusumi S, Fujii R and Hinuma S. (2006) Recent advances in mammalian RFamide peptides: the discovery and functional analyses of PrRP, RFRPs and QRFP. Peptides 27: 1073-86 [PMID:16500002]
  9. Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S and Fujino M. (2003) A new peptidic ligand and its receptor regulating adrenal function in rats. J. Biol. Chem. 278: 46387-95 [PMID:12960173]
  10. Georgsson J, Bergström F, Nordqvist A, Watson MJ, Blundell CD, Johansson MJ, Petersson AU, Yuan ZQ, Zhou Y and Kristensson L et al.. (2014) GPR103 antagonists demonstrating anorexigenic activity in vivo: design and development of pyrrolo[2,3-c]pyridines that mimic the C-terminal Arg-Phe motif of QRFP26. J. Med. Chem. 57: 5935-48 [PMID:24937104]
  11. Georgsson J, Bergström F, Nordqvist A, Watson MJ, Blundell CD, Johansson MJ, Petersson AU, Yuan ZQ, Zhou Y and Kristensson L et al.. (2015) Correction to GPR103 Antagonists Demonstrating Anorexigenic Activity in Vivo: Design and Development of Pyrrolo[2,3-c]pyridines That Mimic the C-Terminal Arg-Phe Motif of QRFP26. J. Med. Chem. 58: 4086 [PMID:25875054]
  12. Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM and Behan J et al.. (2003) Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. J. Biol. Chem. 278: 27652-7 [PMID:12714592]
  13. Kampe J, Wiedmer P, Pfluger PT, Castaneda TR, Burget L, Mondala H, Kerr J, Liaw C, Oldfield BJ and Tschöp MH et al.. (2006) Effect of central administration of QRFP(26) peptide on energy balance and characterization of a second QRFP receptor in rat. Brain Res. 1119: 133-49 [PMID:16996040]
  14. Kuc RE, Mitchell JD and Davenport AD. (2006) The novel ligand [125I]-QRFP43 reveals a remarkably discrete distribution of the orphan receptor GPR103 in human adrenal. Proceedings of the British Pharmacological Society 4: abst186
  15. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR and O'Dowd BF. (2001) Discovery and mapping of ten novel G protein-coupled receptor genes. Gene 275: 83-91 [PMID:11574155]
  16. Leprince J, Bagnol D, Bureau R, Fukusumi S, Granata R, Hinuma S, Larhammar D, Primeaux S, Sopkova-de Oliveiras Santos J and Tsutsui K et al.. (2017) The Arg-Phe-amide peptide 26RFa/glutamine RF-amide peptide and its receptor: IUPHAR Review 24. Br. J. Pharmacol. 174: 3573-3607 [PMID:28613414]
  17. Moriya R, Sano H, Umeda T, Ito M, Takahashi Y, Matsuda M, Ishihara A, Kanatani A and Iwaasa H. (2006) RFamide peptide QRFP43 causes obesity with hyperphagia and reduced thermogenesis in mice. Endocrinology 147: 2916-22 [PMID:16543370]
  18. Navarro VM, Fernández-Fernández R, Nogueiras R, Vigo E, Tovar S, Chartrel N, Le Marec O, Leprince J, Aguilar E and Pinilla L et al.. (2006) Novel role of 26RFa, a hypothalamic RFamide orexigenic peptide, as putative regulator of the gonadotropic axis. J. Physiol. (Lond.) 573: 237-49 [PMID:16543265]
  19. Neveu C, Lefranc B, Tasseau O, Do-Rego JC, Bourmaud A, Chan P, Bauchat P, Le Marec O, Chuquet J and Guilhaudis L et al.. (2012) Rational design of a low molecular weight, stable, potent, and long-lasting GPR103 aza-β3-pseudopeptide agonist. J. Med. Chem. 55: 7516-24 [PMID:22800498]
  20. Patel SR, Murphy KG, Thompson EL, Patterson M, Curtis AE, Ghatei MA and Bloom SR. (2008) Pyroglutamylated RFamide peptide 43 stimulates the hypothalamic-pituitary-gonadal axis via gonadotropin-releasing hormone in rats. Endocrinology 149: 4747-54 [PMID:18535111]
  21. Southern C, Cook JM, Neetoo-Isseljee Z, Taylor DL, Kettleborough CA, Merritt A, Bassoni DL, Raab WJ, Quinn E and Wehrman TS et al.. (2013) Screening β-Arrestin Recruitment for the Identification of Natural Ligands for Orphan G-Protein-Coupled Receptors. J Biomol Screen 18: 599-609 [PMID:23396314]
  22. Takayasu S, Sakurai T, Iwasaki S, Teranishi H, Yamanaka A, Williams SC, Iguchi H, Kawasawa YI, Ikeda Y and Sakakibara I et al.. (2006) A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. Proc. Natl. Acad. Sci. U.S.A. 103: 7438-43 [PMID:16648250]
  23. Zhang Q, Qiu P, Arreaza MG, Simon JS, Golovko A, Laverty M, Vassileva G, Gustafson EL, Rojas-Triana A and Bober LA et al.. (2007) P518/Qrfp sequence polymorphisms in SAMP6 osteopenic mouse. Genomics 90: 629-35 [PMID:17869477]