IUPHAR/BPS Guide to Pharmacology CITE

Parathyroid hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Alessandro Bisello1, Michael Chorev2, Peter A. Friedman1, Tom Gardella3, Rebecca Hills4, Harald Jueppner3, T. John Martin5, Robert A. Nissenson6, John Thomas Potts, Jr.3, Caroline Silve7, Ted B. Usdin8 and Jean-Pierre Vilardaga1
  1. University of Pittsburgh, USA
  2. Harvard Medical School, USA
  3. Massachusetts General Hospital, USA
  4. University of Edinburgh, UK
  5. University of Melbourne, Australia
  6. University of California San Francisco, USA
  7. INSERM, France
  8. National Institute of Mental Health, USA


The parathyroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Parathyroid Hormone Receptors [47]) are family B G protein-coupled receptors. The parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor (PTH1 receptor) is activated by precursor-derived peptides: PTH (84 amino acids), and PTHrP (141 amino-acids) and related peptides (PTH-(1-34), PTHrP-(1-36)). The parathyroid hormone 2 receptor (PTH2 receptor) is activated by the precursor-derived peptide TIP39 (39 amino acids). [125I]PTH may be used to label both PTH1 and PTH2 receptors.


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Database links

Parathyroid hormone receptors
Introduction to Parathyroid hormone receptors
            PTH1 receptor
            PTH2 receptor


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