IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F51/2019.4

Orexin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



Paul Coleman1, Luis de Lecea2, Anthony Gotter1, Jim Hagan3, Rebecca Hills4, Thomas Kilduff5, Jyrki P. Kukkonen6, Rod Porter3, John Renger1, Jerome M Siegel7, Gregor Sutcliffe2, Neil Upton3 and Christopher J. Winrow1
  1. Merck Research Laboratories, USA
  2. Scripps Research Institute, USA
  3. GlaxoSmithKline, UK
  4. University of Edinburgh, UK
  5. SRI International, USA
  6. University of Helsinki, Finland
  7. University of California Los Angeles, USA


Abstract

Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [39]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, preproorexin or orexin precursor, by proteolytic cleavage and some typical peptide modifications [102]. Currently the only orexin receptor ligand in clinical use is suvorexant, which is used as a hypnotic. Orexin receptor crystal structures have been solved [124, 123].

Contents

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Database links

Orexin receptors
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=51
Introduction to Orexin receptors
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=51
    Receptors
            OX1 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=321
            OX2 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=322

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