IUPHAR/BPS Guide to Pharmacology CITE

Hydroxycarboxylic acid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Steven L. Colletti1, Adriaan P. IJzerman2, Timothy W. Lovenberg3, Stefan Offermanns4, Graeme Semple5, M. Gerard Waters1 and Alan Wise6
  1. Merck Research Laboratories, USA
  2. Leiden University, The Netherlands
  3. Janssen Research & Development, USA
  4. Goethe-University Frankfurt, Germany
  5. Beacon Discovery Inc, USA
  6. GlaxoSmithKline, UK


The hydroxycarboxylic acid family of receptors (ENSFM00500000271913, nomenclature as agreed by the NC-IUPHAR Subcommittee on Hydroxycarboxylic acid receptors [32, 10]) respond to organic acids, including the endogenous hydroxy carboxylic acids 3-hydroxy butyric acid and L-lactic acid, as well as the lipid lowering agents nicotinic acid (niacin), acipimox and acifran [47, 54, 57]. These receptors were provisionally described as nicotinic acid receptors, although nicotinic acid shows submicromolar potency at HCA2 receptors only and is unlikely to be the natural ligand [54, 57].


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Database links

Hydroxycarboxylic acid receptors
Introduction to Hydroxycarboxylic acid receptors
            HCA1 receptor
            HCA2 receptor
            HCA3 receptor


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