IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F47/2019.4

Neurotensin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



Jean Mazella1, Philippe Sarret2 and Jean-Pierre Vincent1
  1. CNRS Valbonne, France
  2. Université de Sherbrooke, Canada


Abstract

Neurotensin receptors (nomenclature as recommended by NC-IUPHAR [38]) are activated by the endogenous tridecapeptide neurotensin (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) derived from a precursor (NTS, 30990), which also generates neuromedin N, an agonist at the NTS2 receptor. [3H]neurotensin (human, mouse, rat) and [125I]neurotensin (human, mouse, rat) may be used to label NTS1 and NTS2 receptors at 0.1-0.3 and 3-5 nM concentrations respectively.

Contents

This is a citation summary for Neurotensin receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts.

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Neurotensin receptors
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=47
Introduction to Neurotensin receptors
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=47
    Receptors
            NTS1 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=309
            NTS2 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=310

References

  1. Alexander MJ and Leeman SE. (1998) Widespread expression in adult rat forebrain of mRNA encoding high-affinity neurotensin receptor. J. Comp. Neurol. 402: 475-500 [PMID:9862322]
  2. Amar S, Kitabgi P and Vincent JP. (1986) Activation of phosphatidylinositol turnover by neurotensin receptors in the human colonic adenocarcinoma cell line HT29. FEBS Lett. 201: 31-6 [PMID:3011505]
  3. Amar S, Kitabgi P and Vincent JP. (1987) Stimulation of inositol phosphate production by neurotensin in neuroblastoma N1E115 cells: implication of GTP-binding proteins and relationship with the cyclic GMP response. J. Neurochem. 49: 999-1006 [PMID:3040912]
  4. Amar S, Mazella J, Checler F, Kitabgi P and Vincent JP. (1985) Regulation of cyclic GMP levels by neurotensin in neuroblastoma clone N1E115. Biochem. Biophys. Res. Commun. 129: 117-25 [PMID:2988544]
  5. Araki K, Tachibana S, Uchiyama M, Nakajima T and Yasuhara T. (1975) Isolation and structure of a new active peptide xenopsin on rat stomach strip and some biogenic amines in the skin of Xenopus laevis. Chem Pharm Bull (Tokyo) 23: 3132-3140 [PMID:1218451]
  6. Asselin ML, Dubuc I, Coquerel A and Costentin J. (2001) Localization of neurotensin NTS2 receptors in rat brain, using. Neuroreport 12: 1087-1091 [PMID:11303751]
  7. Azriel Y and Burcher E. (2001) Characterization and autoradiographic localization of neurotensin binding sites in human sigmoid colon. J. Pharmacol. Exp. Ther. 297: 1074-81 [PMID:11356931]
  8. Beaudet A, Nouel D, Stroh T, Vandenbulcke F, Dal-Farra C and Vincent JP. (1998) Fluorescent ligands for studying neuropeptide receptors by confocal microscopy. Braz. J. Med. Biol. Res. 31: 1479-89 [PMID:9921286]
  9. Botto JM, Chabry J, Sarret P, Vincent JP and Mazella J. (1998) Stable expression of the mouse levocabastine-sensitive neurotensin receptor in HEK 293 cell line: binding properties, photoaffinity labeling, and internalization mechanism. Biochem. Biophys. Res. Commun. 243: 585-90 [PMID:9480852]
  10. Botto JM, Guillemare E, Vincent JP and Mazella J. (1997) Effects of SR 48692 on neurotensin-induced calcium-activated chloride currents in the Xenopus oocyte expression system: agonist-like activity on the levocabastine-sensitive neurotensin receptor and absence of antagonist effect on the levocabastine insensitive neurotensin receptor. Neurosci. Lett. 223: 193-6 [PMID:9080465]
  11. Botto JM, Sarret P, Vincent JP and Mazella J. (1997) Identification and expression of a variant isoform of the levocabastine-sensitive neurotensin receptor in the mouse central nervous system. FEBS Lett. 400: 211-4 [PMID:9001400]
  12. Botto JM, Vincent JP and Mazella J. (1997) Existence of two translation initiation sites leading to the expression of two proteins from the rat high-affinity neurotensin-receptor cDNA: possible regulation by the 5' end non-coding region. Biochem. J. 324 ( Pt 2): 389-93 [PMID:9182695]
  13. Boudin H, Lazaroff B, Bachelet CM, Pélaprat D, Rostène W and Beaudet A. (2000) Immunologic differentiation of two high-affinity neurotensin receptor isoforms in the developing rat brain. J. Comp. Neurol. 425: 45-57 [PMID:10940941]
  14. Boudin H, Pélaprat D, Rostène W and Beaudet A. (1996) Cellular distribution of neurotensin receptors in rat brain: immunohistochemical study using an antipeptide antibody against the cloned high affinity receptor. J. Comp. Neurol. 373: 76-89 [PMID:8876464]
  15. Boudin H, Pélaprat D, Rostène W, Pickel VM and Beaudet A. (1998) Correlative ultrastructural distribution of neurotensin receptor proteins and binding sites in the rat substantia nigra. J. Neurosci. 18: 8473-84 [PMID:9763490]
  16. Boules M, Shaw A, Liang Y, Barbut D and Richelson E. (2009) NT69L, a novel analgesic, shows synergy with morphine. Brain Res. 1294: 22-8 [PMID:19651107]
  17. Bozou JC, Amar S, Vincent JP and Kitabgi P. (1986) Neurotensin-mediated inhibition of cyclic AMP formation in neuroblastoma N1E115 cells: involvement of the inhibitory GTP-binding component of adenylate cyclase. Mol. Pharmacol. 29: 489-96 [PMID:3010077]
  18. Béraud-Dufour S, Coppola T, Massa F and Mazella J. (2009) Neurotensin receptor-2 and -3 are crucial for the anti-apoptotic effect of neurotensin on pancreatic beta-TC3 cells. Int. J. Biochem. Cell Biol. 41: 2398-402 [PMID:19891061]
  19. Carraway R and Leeman SE. (1973) The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami. J. Biol. Chem. 248: 6854-61 [PMID:4745447]
  20. Chabry J, Gaudriault G, Vincent JP and Mazella J. (1993) Implication of various forms of neurotensin receptors in the mechanism of internalization of neurotensin in cerebral neurons. J. Biol. Chem. 268: 17138-44 [PMID:8394329]
  21. Chabry J, Labbé-Jullié C, Gully D, Kitabgi P, Vincent JP and Mazella J. (1994) Stable expression of the cloned rat brain neurotensin receptor into fibroblasts: binding properties, photoaffinity labeling, transduction mechanisms, and internalization. J Neurochem 63: 19-27 [PMID:8207427]
  22. Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, Le Fur G, Ferrara P and Caput D. (1996) Molecular cloning of a levocabastine-sensitive neurotensin binding site. FEBS Lett. 386: 91-4 [PMID:8647296]
  23. Choi KE, Hall CL, Sun JM, Wei L, Mohamad O, Dix TA and Yu SP. (2012) A novel stroke therapy of pharmacologically induced hypothermia after focal cerebral ischemia in mice. FASEB J. 26: 2799-810 [PMID:22459147]
  24. Choi SY, Chae HD, Park TJ, Ha H and Kim KT. (1999) Characterization of high affinity neurotensin receptor NTR1 in HL-60 cells and its down regulation during granulocytic differentiation. Br. J. Pharmacol. 126: 1050-6 [PMID:10193787]
  25. Coppola T, Béraud-Dufour S, Antoine A, Vincent JP and Mazella J. (2008) Neurotensin protects pancreatic beta cells from apoptosis. Int. J. Biochem. Cell Biol. 40: 2296-302 [PMID:18456542]
  26. Craig AG, Norberg T, Griffin D, Hoeger C, Akhtar M, Schmidt K, Low W, Dykert J, Richelson E and Navarro V et al.. (1999) Contulakin-G, an O-glycosylated invertebrate neurotensin. J. Biol. Chem. 274: 13752-9 [PMID:10318778]
  27. Croci T, Aureggi G, Guagnini F, Manara L, Gully D, Fur GL, Maffrand JP, Mukenge S, Ferla G and Ferrara P et al.. (1999) In vitro functional evidence of different neurotensin-receptors modulating the motor response of human colonic muscle strips. Br. J. Pharmacol. 127: 1922-8 [PMID:10482925]
  28. Cusack B, Jansen K, McCormick DJ, Chou T, Pang Y and Richelson E. (2000) A single amino acid of the human and rat neurotensin receptors (subtype 1) determining the pharmacological profile of a species-selective neurotensin agonist. Biochem. Pharmacol. 60: 793-801 [PMID:10930533]
  29. Cáceda R, Kinkead B, Owens MJ and Nemeroff CB. (2005) Virally mediated increased neurotensin 1 receptor in the nucleus accumbens decreases behavioral effects of mesolimbic system activation. J. Neurosci. 25: 11748-56 [PMID:16354933]
  30. Dobner PR, Barber DL, Villa-Komaroff L and McKiernan C. (1987) Cloning and sequence analysis of cDNA for the canine neurotensin/neuromedin N precursor. Proc Natl Acad Sci U S A 84: 3516-3520 [PMID:3472221]
  31. Doré-Savard L, Roussy G, Dansereau MA, Collingwood MA, Lennox KA, Rose SD, Beaudet N, Behlke MA and Sarret P. (2008) Central delivery of Dicer-substrate siRNA: a direct application for pain research. Mol. Ther. 16: 1331-9 [PMID:18523447]
  32. Doulut S, Rodriguez M, Lugrin D, Vecchini F, Kitabgi P, Aumelas A and Martinez J. (1992) Reduced peptide bond pseudopeptide analogues of neurotensin. Pept. Res. 5: 30-8 [PMID:1623301]
  33. Dubuc I, Sarret P, Labbé-Jullié C, Botto JM, Honoré E, Bourdel E, Martinez J, Costentin J, Vincent JP and Kitabgi P et al.. (1999) Identification of the receptor subtype involved in the analgesic effect of neurotensin. J. Neurosci. 19: 503-10 [PMID:9870978]
  34. edCarraway RE, Pothoulakis C and Leeman S. (2006) Neurotensin: Roles and Mechanisms. Peptides 27: 2361-2534
  35. Elde R, Schalling M, Ceccatelli S, Nakanishi S and Hökfelt T. (1990) Localization of neuropeptide receptor mRNA in rat brain: initial observations using probes for neurotensin and substance P receptors. Neurosci. Lett. 120: 134-8 [PMID:1705671]
  36. Fantegrossi WE, Ko MC, Woods JH and Richelson E. (2005) Antinociceptive, hypothermic, hypotensive, and reinforcing effects of a novel neurotensin receptor agonist, NT69L, in rhesus monkeys. Pharmacol. Biochem. Behav. 80: 341-9 [PMID:15680187]
  37. Fassio A, Evans G, Grisshammer R, Bolam JP, Mimmack M and Emson PC. (2000) Distribution of the neurotensin receptor NTS1 in the rat CNS studied using an amino-terminal directed antibody. Neuropharmacology 39: 1430-42 [PMID:10818259]
  38. Foord SM, Bonner TI, Neubig RR, Rosser EM, Pin JP, Davenport AP, Spedding M and Harmar AJ. (2005) International Union of Pharmacology. XLVI. G protein-coupled receptor list. Pharmacol. Rev. 57: 279-88 [PMID:15914470]
  39. Friry C, Feliciangeli S, Richard F, Kitabgi P and Rovere C. (2002) Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and biological activity. Biochem. Biophys. Res. Commun. 290: 1161-8 [PMID:11811984]
  40. Gailly P. (1998) Ca2+ entry in CHO cells, after Ca2+ stores depletion, is mediated by arachidonic acid. Cell Calcium 24: 293-304 [PMID:9883283]
  41. Gailly P, Najimi M and Hermans E. (2000) Evidence for the dual coupling of the rat neurotensin receptor with pertussis toxin-sensitive and insensitive G-proteins. FEBS Lett. 483: 109-13 [PMID:11042263]
  42. Gendron L, Perron A, Payet MD, Gallo-Payet N, Sarret P and Beaudet A. (2004) Low-affinity neurotensin receptor (NTS2) signaling: internalization-dependent activation of extracellular signal-regulated kinases 1/2. Mol. Pharmacol. 66: 1421-30 [PMID:15361549]
  43. Gilbert JA and Richelson E. (1984) Neurotensin stimulates formation of cyclic GMP in murine neuroblastoma clone N1E-115. Eur. J. Pharmacol. 99: 245-6 [PMID:6329783]
  44. Guillemette A, Dansereau MA, Beaudet N, Richelson E and Sarret P. (2012) Intrathecal administration of NTS1 agonists reverses nociceptive behaviors in a rat model of neuropathic pain. Eur J Pain 16: 473-84 [PMID:22396077]
  45. Gully D, Canton M, Boigegrain R, Jeanjean F, Molimard JC, Poncelet M, Gueudet C, Heaulme M, Leyris R and Brouard A et al.. (1993) Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor. Proc. Natl. Acad. Sci. U.S.A. 90: 65-9 [PMID:8380498]
  46. Gully D, Labeeuw B, Boigegrain R, Oury-Donat F, Bachy A, Poncelet M, Steinberg R, Suaud-Chagny MF, Santucci V and Vita N et al.. (1997) Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. J. Pharmacol. Exp. Ther. 280: 802-12 [PMID:9023294]
  47. Hadden MK, Orwig KS, Kokko KP, Mazella J and Dix TA. (2005) Design, synthesis, and evaluation of the antipsychotic potential of orally bioavailable neurotensin (8-13) analogues containing non-natural arginine and lysine residues. Neuropharmacology 49: 1149-59 [PMID:16095636]
  48. Hermans E, Geurts M and Maloteaux JM. (1997) Agonist and antagonist modulation of [35S]-GTP gamma S binding in transfected CHO cells expressing the neurotensin receptor. Br. J. Pharmacol. 121: 1817-23 [PMID:9283723]
  49. Hermans E, Maloteaux JM and Octave JN. (1992) Phospholipase C activation by neurotensin and neuromedin N in Chinese hamster ovary cells expressing the rat neurotensin receptor. Brain Res. Mol. Brain Res. 15: 332-8 [PMID:1331689]
  50. Hughes FM, Shaner BE, May LA, Zotian L, Brower JO, Woods RJ, Cash M, Morrow D, Massa F and Mazella J et al.. (2010) Identification and functional characterization of a stable, centrally active derivative of the neurotensin (8-13) fragment as a potential first-in-class analgesic. J. Med. Chem. 53: 4623-32 [PMID:20481538]
  51. Kitabgi P, Rostène W, Dussaillant M, Schotte A, Laduron PM and Vincent JP. (1987) Two populations of neurotensin binding sites in murine brain: discrimination by the antihistamine levocabastine reveals markedly different radioautographic distribution. Eur. J. Pharmacol. 140: 285-93 [PMID:2888670]
  52. Labbé-Jullié C, Barroso S, Nicolas-Etève D, Reversat JL, Botto JM, Mazella J, Bernassau JM and Kitabgi P. (1998) Mutagenesis and modeling of the neurotensin receptor NTR1. Identification of residues that are critical for binding SR 48692, a nonpeptide neurotensin antagonist. J. Biol. Chem. 273: 16351-7 [PMID:9632698]
  53. Labbé-Jullié C, Botto JM, Mas MV, Chabry J, Mazella J, Vincent JP, Gully D, Maffrand JP and Kitabgi P. (1995) [3H]SR 48692, the first nonpeptide neurotensin antagonist radioligand: characterization of binding properties and evidence for distinct agonist and antagonist binding domains on the rat neurotensin receptor. Mol. Pharmacol. 47: 1050-6 [PMID:7746272]
  54. Lafrance M, Roussy G, Belleville K, Maeno H, Beaudet N, Wada K and Sarret P. (2010) Involvement of NTS2 receptors in stress-induced analgesia. Neuroscience 166: 639-52 [PMID:20035838]
  55. Laurent P, Clerc P, Mattei MG, Forgez P, Dumont X, Ferrara P, Caput D and Rostene W. (1994) Chromosomal localization of mouse and human neurotensin receptor genes. Mamm Genome 5: 303-306 [PMID:8075503]
  56. Le F, Groshan K, Zeng XP and Richelson E. (1997) Characterization of the genomic structure, promoter region, and a tetranucleotide repeat polymorphism of the human neurotensin receptor gene. J. Biol. Chem. 272: 1315-22 [PMID:8995438]
  57. Leonetti M, Brun P, Clerget M, Steinberg R, Soubrié P, Renaud B and Suaud-Chagny MF. (2004) Specific involvement of neurotensin type 1 receptor in the neurotensin-mediated in vivo dopamine efflux using knock-out mice. J. Neurochem. 89: 1-6 [PMID:15030383]
  58. Maeno H, Yamada K, Santo-Yamada Y, Aoki K, Sun YJ, Sato E, Fukushima T, Ogura H, Araki T and Kamichi S et al.. (2004) Comparison of mice deficient in the high- or low-affinity neurotensin receptors, Ntsr1 or Ntsr2, reveals a novel function for Ntsr2 in thermal nociception. Brain Res. 998: 122-9 [PMID:14725975]
  59. Martin S, Botto JM, Vincent JP and Mazella J. (1999) Pivotal role of an aspartate residue in sodium sensitivity and coupling to G proteins of neurotensin receptors. Mol. Pharmacol. 55: 210-5 [PMID:9927610]
  60. Martin S, Navarro V, Vincent JP and Mazella J. (2002) Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line. Gastroenterology 123: 1135-43 [PMID:12360476]
  61. Mazella J, Botto JM, Guillemare E, Coppola T, Sarret P and Vincent JP. (1996) Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain. J. Neurosci. 16: 5613-20 [PMID:8795617]
  62. Mazella J, Poustis C, Labbe C, Checler F, Kitabgi P, Granier C, van Rietschoten J and Vincent JP. (1983) Monoiodo-[Trp11]neurotensin, a highly radioactive ligand of neurotensin receptors. Preparation, biological activity, and binding properties to rat brain synaptic membranes. J. Biol. Chem. 258: 3476-81 [PMID:6300046]
  63. Mechanic JA, Sutton JE, Berson AE, Wu X, Kwan J, Schreiber R, Pang Z and Button DC. (2009) Involvement of the neurotensin receptor 1 in the behavioral effects of two neurotensin agonists, NT-2 and NT69L: lack of hypothermic, antinociceptive and antipsychotic actions in receptor knockout mice. Eur Neuropsychopharmacol 19: 466-75 [PMID:19223157]
  64. Moyse E, Rostène W, Vial M, Leonard K, Mazella J, Kitabgi P, Vincent JP and Beaudet A. (1987) Distribution of neurotensin binding sites in rat brain: a light microscopic radioautographic study using monoiodo [125I]Tyr3-neurotensin. Neuroscience 22: 525-36 [PMID:3313097]
  65. Mulè F, Serio R, Postorino A, Vetri T and Bonvissuto F. (1996) Antagonism by SR 48692 of mechanical responses to neurotensin in rat intestine. Br. J. Pharmacol. 117: 488-492 [PMID:8821538]
  66. Najimi M, Gailly P, Maloteaux JM and Hermans E. (2002) Distinct regions of C-terminus of the high affinity neurotensin receptor mediate the functional coupling with pertussis toxin sensitive and insensitive G-proteins. FEBS Lett 512: 329-333 [PMID:11852105]
  67. Nielsen MS, Jacobsen C, Olivecrona G, Gliemann J and Petersen CM. (1999) Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J. Biol. Chem. 274: 8832-6 [PMID:10085125]
  68. Nouel D, Sarret P, Vincent JP, Mazella J and Beaudet A. (1999) Pharmacological, molecular and functional characterization of glial neurotensin receptors. Neuroscience 94: 1189-97 [PMID:10625058]
  69. Oury-Donat F, Thurneyssen O, Gonalons N, Forgez P, Gully D, Le Fur G and Soubrie P. (1995) Characterization of the effect of SR48692 on inositol monophosphate, cyclic GMP and cyclic AMP responses linked to neurotensin receptor activation in neuronal and non-neuronal cells. Br. J. Pharmacol. 116: 1899-905 [PMID:8528577]
  70. Pereyra-Alfonso S, López Ordieres MG, del V Armanino M and de Lores Arnaiz GR. (2005) High-affinity neurotensin receptor is involved in phosphoinositide hydrolysis stimulation by carbachol in neonatal rat brain. Brain Res. Dev. Brain Res. 154: 247-54 [PMID:15707678]
  71. Perron A, Sarret P, Gendron L, Stroh T and Beaudet A. (2005) Identification and functional characterization of a 5-transmembrane domain variant isoform of the NTS2 neurotensin receptor in rat central nervous system. J. Biol. Chem. 280: 10219-27 [PMID:15637074]
  72. Pettibone DJ, Hess JF, Hey PJ, Jacobson MA, Leviten M, Lis EV, Mallorga PJ, Pascarella DM, Snyder MA and Williams JB et al.. (2002) The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin. J. Pharmacol. Exp. Ther. 300: 305-13 [PMID:11752130]
  73. Pipkorn U, Bende M, Hedner J and Hedner T. (1985) A double-blind evaluation of topical levocabastine, a new specific H1 antagonist in patients with allergic conjunctivitis. Allergy 40: 491-6 [PMID:2866725]
  74. Poinot-Chazel C, Portier M, Bouaboula M, Vita N, Pecceu F, Gully D, Monroe JG, Maffrand JP, Le Fur G and Casellas P. (1996) Activation of mitogen-activated protein kinase couples neurotensin receptor stimulation to induction of the primary response gene Krox-24. Biochem. J. 320 ( Pt 1): 145-51 [PMID:8947479]
  75. Poncelet M, Souilhac J, Gueudet C, Terranova JP, Gully D, Le Fur G and Soubrié P. (1994) Effects of SR 48692, a selective non-peptide neurotensin receptor antagonist, on two dopamine-dependent behavioural responses in mice and rats. Psychopharmacology (Berl.) 116: 237-41 [PMID:7862953]
  76. Portier M, Combes T, Gully D, Maffrand JP and Casellas P. (1998) Neurotensin type 1 receptor-mediated activation of krox24, c-fos and Elk-1: preventing effect of the neurotensin antagonists SR 48692 and SR 142948. FEBS Lett. 432: 88-93 [PMID:9710257]
  77. Poustis C, Mazella J, Kitabgi P and Vincent JP. (1984) High-affinity neurotensin binding sites in differentiated neuroblastoma N1E115 cells. J. Neurochem. 42: 1094-100 [PMID:6699640]
  78. Remaury A, Vita N, Gendreau S, Jung M, Arnone M, Poncelet M, Culouscou JM, Le Fur G, Soubrié P and Caput D et al.. (2002) Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia. Brain Res. 953: 63-72 [PMID:12384239]
  79. Richard F, Barroso S, Martinez J, Labbé-Jullié C and Kitabgi P. (2001) Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2. Mol. Pharmacol. 60: 1392-8 [PMID:11723247]
  80. Roussy G, Beaudry H, Lafrance M, Belleville K, Beaudet N, Wada K, Gendron L and Sarret P. (2010) Altered morphine-induced analgesia in neurotensin type 1 receptor null mice. Neuroscience 170: 1286-94 [PMID:20727387]
  81. Roussy G, Dansereau MA, Baudisson S, Ezzoubaa F, Belleville K, Beaudet N, Martinez J, Richelson E and Sarret P. (2009) Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity. Mol Pain 5: 38 [PMID:19580660]
  82. Roussy G, Dansereau MA, Doré-Savard L, Belleville K, Beaudet N, Richelson E and Sarret P. (2008) Spinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain model. J. Neurochem. 105: 1100-14 [PMID:18182046]
  83. Sarret P, Beaudet A, Vincent JP and Mazella J. (1998) Regional and cellular distribution of low affinity neurotensin receptor mRNA in adult and developing mouse brain. J Comp Neurol 394: 344-356 [PMID:9579398]
  84. Sarret P, Esdaile MJ, Perron A, Martinez J, Stroh T and Beaudet A. (2005) Potent spinal analgesia elicited through stimulation of NTS2 neurotensin receptors. J. Neurosci. 25: 8188-96 [PMID:16148226]
  85. Sarret P, Gendron L, Kilian P, Nguyen HM, Gallo-Payet N, Payet MD and Beaudet A. (2002) Pharmacology and functional properties of NTS2 neurotensin receptors in cerebellar granule cells. J. Biol. Chem. 277: 36233-43 [PMID:12084713]
  86. Sarret P, Perron A, Stroh T and Beaudet A. (2003) Immunohistochemical distribution of NTS2 neurotensin receptors in the rat central nervous system. J. Comp. Neurol. 461: 520-38 [PMID:12746866]
  87. Sarrieau A, Javoy-Agid F, Kitabgi P, Dussaillant M, Vial M, Vincent JP, Agid Y and Rostène WH. (1985) Characterization and autoradiographic distribution of neurotensin binding sites in the human brain. Brain Res. 348: 375-80 [PMID:4075096]
  88. Schaeffer P, Laplace MC, Savi P, Pflieger AM, Gully D and Herbert JM. (1995) Human umbilical vein endothelial cells express high affinity neurotensin receptors coupled to intracellular calcium release. J. Biol. Chem. 270: 3409-13 [PMID:7852427]
  89. Skrzydelski D, Lhiaubet AM, Lebeau A, Forgez P, Yamada M, Hermans E, Rostene W and Pelaprat D. (2003) Differential involvement of intracellular domains of the rat NTS1 neurotensin receptor in coupling to G proteins: a molecular basis for agonist-directed trafficking of receptor stimulus. Mol. Pharmacol. 64: 421-9 [PMID:12869647]
  90. Smith KE, Boules M, Williams K, Fauq AH and Richelson E. (2011) The role of NTS2 in the development of tolerance to NT69L in mouse models for hypothermia and thermal analgesia. Behav. Brain Res. 224: 344-9 [PMID:21718721]
  91. Snider RM, Forray C, Pfenning M and Richelson E. (1986) Neurotensin stimulates inositol phospholipid metabolism and calcium mobilization in murine neuroblastoma clone N1E-115. J. Neurochem. 47: 1214-8 [PMID:3018165]
  92. Sun YJ, Maeno H, Aoki S and Wada K. (2001) Mouse neurotensin receptor 2 gene (Ntsr2): genomic organization, transcriptional regulation and genetic mapping on chromosome 12. Brain Res. Mol. Brain Res. 95: 167-71 [PMID:11687289]
  93. Tanaka K, Masu M and Nakanishi S. (1990) Structure and functional expression of the cloned rat neurotensin receptor. Neuron 4: 847-54 [PMID:1694443]
  94. Tirado-Santiago G, Lázaro-Muñoz G, Rodríguez-González V and Maldonado-Vlaar CS. (2006) Microinfusions of neurotensin antagonist SR 48692 within the nucleus accumbens core impair spatial learning in rats. Behav. Neurosci. 120: 1093-102 [PMID:17014260]
  95. Vita N, Laurent P, Lefort S, Chalon P, Dumont X, Kaghad M, Gully D, Le Fur G, Ferrara P and Caput D. (1993) Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor. FEBS Lett. 317: 139-42 [PMID:8381365]
  96. Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, Thurneyssen O, Garcia S, Poinot-Chazel C and Casellas P et al.. (1998) Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells. Eur. J. Pharmacol. 360: 265-72 [PMID:9851594]
  97. Watson MA, Yamada M, Yamada M, Cusack B, Veverka K, Bolden-Watson C and Richelson E. (1992) The rat neurotensin receptor expressed in Chinese hamster ovary cells mediates the release of inositol phosphates. J. Neurochem. 59: 1967-70 [PMID:1328536]
  98. White JF, Noinaj N, Shibata Y, Love J, Kloss B, Xu F, Gvozdenovic-Jeremic J, Shah P, Shiloach J and Tate CG et al.. (2012) Structure of the agonist-bound neurotensin receptor. Nature 490: 508-13 [PMID:23051748]
  99. Yamada M, Yamada M, Watson MA and Richelson E. (1993) Neurotensin stimulates cyclic AMP formation in CHO-rNTR-10 cells expressing the cloned rat neurotensin receptor. Eur. J. Pharmacol. 244: 99-101 [PMID:8380559]